급성위점막병변에 대한 실험적 연구 = Experimental Study on Acute Gastric Mucosal Lesion

다국어 초록 (Multilingual Abstract)

It has become traditional to use the term stress ulcer to describe acute gastric mucosal lesions (AGM) proceded by a major stess such as that of an operation or of severe thermal burns or hemorrhagic shock. AGM lesin is a general term applied to conditions characterized by the acute development of mucosal lesions in the form of erythema. mucojal hemorrhage. erosions and ulcerations in the mucosa of the stomach and duodenum.
The salient clinical manifestation of AGM lesions, regardless of thear cause, is bleeding. The purpose of the present investigation was to study the AGM lesion which was experimentally produced in rats by brain injury and administration of steroid.
The experimental animals, normal adult rats, were divided into 4 groups: The first group of brain injury, the second group of brain injury and administration of steroid, the third group of administration of steroid only, and the fourth group of normal control with or without administration of normal saline.
The frequency of AGM lesios was studied in relation to each experimental group, experimental period and grade of lesion. The AGM lesions were divided into 3 grades depending on the macroscopic and micoscopic findings.
AGM lesions were observed in 34 out of 63 experimental animals except for control group of animal. Majority of the lesions were found in the glandular portion of the stomach.
In the brain injured group, the lesions that was eyrthematous and superficial mucosal erosion were found in 3 out of 21 (14.30%), which were observed in experimental period of 3-5 days.
In the group with brain injury and steroid administration, the lesions were found in 16 out of 21 animals (76.2%). Among them grade 1 was in 2 out of 16, grade 2 in 10 and grade 3 in 4, which were observed in the period of 2-7 days.
In the group with administration of steroid, the lesions were found in 15 out of 21 animals (71.4%)
Among them grade 1 was 2 out of 15, grade 2 in 11 and grade 3 in 2, which were able to be observed from 2nd day throughout the experimental period.
No lesions were observed in the control group of animals.

목차 (Table of Contents)

• Ⅰ. 서론
• Ⅱ. 실험재료 및 방법
• Ⅲ. 실험성적
• Ⅳ. 총괄 및 고안
• Ⅴ. 결론
• 참고문헌