정상인과 녹내장 환자의 혈청 인지질 지방산 농도

다국어 초록 (Multilingual Abstract)

Glaucoma is one of the leading causes of blindness worldwide and is characterized by degeneration of the optic nerve. Elevated intraocular pressure (IOP) is the major contributing factor to optic nerve damage. However, some patients develop glaucoma even with normal IOP. Other factors, including age, race, myopia, and nutrition, can affect glaucoma risk. Dietary fat intake and serum fatty acid composition are closely related with the fatty acid profile of the retina and thus can modulate glaucoma risk. In this study, we collected serum samples from 34 glaucoma patients (26 primary open angle glaucoma (POAG) and 8 normal tension glaucoma (NTG)) and 45 healthy controls and analyzed their serum phospholipid fatty acid concentrations. The results show that the ratio of oleic acid to stearic acid (OA/SA), which is an indicator of stearoyl-CoA desaturase activity, was higher in POAG patients when compared to normal controls. The ratio of eicosapentaenoic acid to arachidonic acid (EPA/AA), which is an indirect marker of eicosanoid biosynthesis, was also higher in glaucoma patients (p=0.048). These results imply that dietary fatty acid intake and serum fatty acid profile can influence glaucoma risk. Additional study is necessary to identify the relationship between fatty acids and glaucoma.

목차 (Table of Contents)

• Abstract
• I. 서 론
• II . 연구 내용 및 방법
• 1. 연구 대상자
• 2. 연구 방법
• III. 결과 및 고찰
• 1. 연구대상자의 일반사항
• 2. 단일불포화 및 포화 지방산 조성 비교
• 3. 다가불포화 지방산 조성 비교
• IV. 요약 및 결론
• References

참고문헌 (Reference)

1 Heintz N, "alpha-Synuclein--a link between Parkinson and Alzheimer diseases?" 16 (16): 325-327, 1997

2 Pelletier AL, "Vision loss in older adults" 94 (94): 219-226, 2016

3 Hoffman DR, "Toward optimizing vision and cognition in term infants by dietary docosahexaenoic and arachidonic acid supplementation: a review of randomized controlled trials" 81 (81): 151-158, 2009

4 Baylin A, "The use of fatty acid biomarkers to reflect dietary intake" 17 (17): 22-27, 2006

5 Yehuda S, "The role of polyunsaturated fatty acids in restoring the aging neuronal membrane" 23 (23): 843-853, 2002

6 SanGiovanni JP, "The role of omega-3 longchain polyunsaturated fatty acids in health and disease of the retina" 24 (24): 87-138, 2005

7 Ramdas WD, "The relation between dietary intake and glaucoma: a systematic review" 96 (96): 550-556, 2018

8 Weinreb RN, "The pathophysiology and treatment of glaucoma : a review" 311 (311): 1901-1911, 2014

9 Simopoulos AP, "The omega-6/omega-3 fatty acid ratio, genetic variation, and cardiovascular disease" 17 (17): 131-134, 2008

10 Quigley HA, "The number of people with glaucoma worldwide in 2010 and 2020" 90 (90): 262-267, 2006

11 Flammer J, "The impact of ocular blood flow in glaucoma" 21 (21): 359-393, 2002

12 Lee BL, "The definition of normal-tension glaucoma" 7 (7): 366-371, 1998

13 Higginbotham EJ, "The Ocular Hypertension Treatment Study: topical medication delays or prevents primary open-angle glaucoma in African American individuals" 122 (122): 813-820, 2004

14 Faralli JA, "Role of fibronectin in primary open angle glaucoma" 8 (8): pii: E1518-, 2019

15 Ren H, "Primary open-angle glaucoma patients have reduced levels of blood docosahexaenoic and eicosapentaenoic acids" 74 (74): 157-163, 2006

16 Varma R, "Prevalence of open-angle glaucoma and ocular hypertension in Latinos: the Los Angeles Latino Eye Study" 111 (111): 1439-1448, 2004

17 Innis SM., "Present knowledge in nutrition" ILSI Press 58-66, 1996

18 Folch J, "Preparation of lipide extracts from brain tissue" 191 (191): 833-841, 1951

19 Cho HK, "Population-based glaucoma prevalence studies in Asians" 59 (59): 434-447, 2014

20 Prez de Arcelus M, "Omega 3:6 ratio intake and incidence of glaucoma: the SUN cohort" 33 (33): 1041-1045, 2014

21 Renard JP, "Nutritional, lifestyle and environmental factors in ocular hypertension and primary open-angle glaucoma: an exploratory case-control study" 91 (91): 505-513, 2013

22 Ramdas WD, "Nutrient intake and risk of open-angle glaucoma: the Rotterdam Study" 27 (27): 385-393, 2012

23 Nucci C, "New strategies for neuroprotection in glaucoma, a disease that affects the central nervous system" 787 : 119-126, 2016

24 Fanning S, "Lipidomic analysis of α-synuclein neurotoxicity identifies stearoyl CoA desaturase as a target for parkinson treatment" 73 (73): 1001-1014, 2019

25 Acar N, "Lipid composition of the human eye: are red blood cells a good mirror of retinal and optic nerve fatty acids?" 7 (7): e35102-, 2012

26 McMonnies CW, "Glaucoma history and risk factors" 10 (10): 71-78, 2017

27 Stjernschantz JW, "From PGF(2alpha)-isopropyl ester to latanoprost: a review of the development of Xalatan" 42 (42): 1134-1145, 2001

28 Kris-Etherton PM, "Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease" 106 (106): 2747-2757, 2002

29 Seo SJ, "Estimated prevalence of glaucoma in South Korea using the national claims database" 1690256-, 2016

30 Resch H, "Endothelial dysfunction in glaucoma" 87 (87): 4-12, 2009

31 Greiner CA, "Distribution of membrane phospholipids in the rabbit neural retina, optic nerve head and optic nerve" 27 (27): 21-28, 1995

32 James MJ, "Dietary polyunsaturated fatty acids and inflammatory mediator production" 71 (71): 343S-348S, 2000

33 Chong EW, "Dietary omega-3 fatty acid and fish intake in the primary prevention of age-related macular degeneration:a systematic review and meta-analysis" 126 (126): 826-833, 2008

34 Innis SM, "Dietary omega 3 fatty acids and the developing brain" 1237 : 35-43, 2008

35 Kang JH, "Dietary fat consumption and primary open-angle glaucoma" 79 (79): 755-764, 2004

36 Thibaut AC, "Correlation between serum phospholipid fatty acids and dietary intakes assessed a few years earlier" 61 (61): 500-509, 2009

37 Semenova EM, "Comparison between oleic acid and docosahexaenoic acid binding to interphotoreceptor retinoid-binding protein" 43 (43): 3063-3067, 2003

38 Merle BM, "Circulating omega-3 Fatty acids and neovascular agerelated macular degeneration" 55 (55): 2010-2019, 2014

39 Fliesler SJ, "Chemistry and metabolism of lipids in the vertebrate retina" 22 (22): 79-131, 1983

40 Innis SM, "Brain astrocyte synthesis of docosahexaenoic acid from n-3 fatty acids is limited at the elongation of docosapentaenoic acid" 43 (43): 1529-1536, 2002

41 Paton CM, "Biochemical and physiological function of stearoyl-CoA desaturase" 297 (297): E28-E37, 2009

42 Mozaffarieh M, "A novel perspective on natural therapeutic approaches in glaucoma therapy" 12 (12): 195-198, 2007

43 Korea ministry of health & welfare, "2015 KDRIs, Dietary reference intakes for Koreans"