Ocular comorbidities in patients with rosacea : A case-control study = Ocular comorbidities in patients with rosacea : A case-control study

다국어 초록 (Multilingual Abstract)

Background: Rosacea is a common acquired inflammatory skin disorder. Although clinical phenotyeps of rosacea includes a variety of ocular manifestations, detailed data on ocular comorbidities among patients with rosacea are still scant.
Objectives: This study aimed to investigate the association between rosacea and ocular comorbidities in Korea.
Methods: We performed a large multi-center case-control study using a multicenter hospital database in Korea from 2007 to 2018. Conditional logistic regression analyses were performed to compare the risk of ocular comorbidities between two groups.
Results: A total of 12,936 cases with rosacea and 12,936 age-, sex-, skin phototype-matched controls without rosacea were enrolled. Patients with rosacea were found to be at increased risk of having blepharitis (adjusted odds ratio [aOR] 3.44; 95% confidence interval [CI] 2.71-4.36), glaucoma (aOR 1.93; 95% CI, 1.70-2.20), conjunctivitis (aOR 1.65; 95% CI, 1.50-1.82), and lacrimal disorder (aOR 1.52; 95% CI, 1.41-1.63).
Conclusion: This study confirms a significant association between rosacea and ocular comorbidities in the Korean population. Of note, we found that increased risk of glaucoma, which could increase the risk of ocular morbidity. Therefore, ophthalmological referral for patients with cutaneous rosacea is needed to provide optimal management of rosacea.