Ulocladium Infection in a Healthy Individual = Ulocladium Infection in a Healthy Individual

다국어 초록 (Multilingual Abstract)

Ulocladium, which is phylogenetically related to Alternaria, contains species that are food spoilers and plant pathogens, but also species that have potential as enzyme producers and bio-control agents. Ulocladium spp. are often found on dead vegetation, in soil, air and dust, but also on food and feedstuffs and on water-damaged building materials. A 67-year-old man presented at our clinic with 3-month history of an ulcer covered with crust on his both fore arms. The primary fungal medium had been incubated at 28°C. A colony appeared at the inoculation site after 4 days. By day 8, the colony had a diameter of 2 cm and was greyish brown and powdery. It was sporulating by this time. Many of the conidia were dark brown and had transverse and longitudinal septa, suggestive of Alternaria species. However, some conidia were coarsely verrucose. The isolate was sent, with clinical details only, to a fungal reference laboratory. It was identified as a Ulocladium species on morphological grounds. Based on the morphological features and molecular identification, the patient was diagnosed as Ulocladium atrum keratitis. He was successfully cured by oral sporanox and topical use of travogen cream. Diagnosis was done by culture isolation, histopathological examination. The main interest of this case is the rareness of Ulocladium atrum keratitis in an healthy individual and we also want to emphasize the good response to therapy.