Tick‐borne viruses: Current trends in large‐scale viral surveillance

다국어 초록 (Multilingual Abstract)

Ticks are ectoparasites that transmit pathogens, such as tick-borne viruses, to their hosts. Tick-borne viruses are diverse: they can be categorized into two orders, nine families, and at least 12 genera. Almost 25% of these viruses are infectious to humans and some are a serious threat to public health. The global rise in tick-borne virus diseases has been linked to climate change which has reduced tick mortality in the winter and extended their active period. The spread of tick-borne viral diseases to humans has received significant interest due to the increased threat to human life; epidemiological monitoring of tick-borne viruses using molecular, immunological, and environmental methods is now a priority. Nevertheless, many tick-borne diseases remain undiagnosed, which poses a challenge to public administration and health care officials. This review discusses three major tick-borne RNA viruses that cause serious infection in humans: severe fever with thrombocytopenia syndrome (SFTS) virus, tick-borne encephalitis (TBE), and Crimean–Congo hemorrhagic fever (CCHF) virus. Specifically, we discuss the epidemiological monitoring, vector control measures, molecular diagnostics, vaccines, and environmental determinants related to these viruses. Furthermore, we review the current surveillance of these tick-borne viruses with a specific focus on diagnostic approaches that employ molecular interventions such as viral nucleic acid isolation, PCR-based diagnostics, and high-throughput sequencing technologies.

참고문헌 (Reference)

1 Orkun Ø, "İç Anadolu Bölgesindeki Sokak Köpeklerinde Kene Kaynaklı Kan Protozoonları Varlığının Araştırılması ve Yüksek Orandaki Hepatozoon Enfeksiyonunun Moleküler Karakterizasyonu" 2017

2 Nuttall PA, "Wonders of tick saliva" 10 : 470-481, 2019

3 Lwande, OW, "Whole genome phylogenetic investigation of a West Nile Virus strain isolated from a tick sampled from livestock in north eastern Kenya" 7 : 542-, 2014

4 Labuda M, "Viruses transmitted by ticks" 2008

5 Cholleti H, "Viral metagenomics reveals the presence of highly divergent quaranjavirus in Rhipicephalus ticks from Mozambique" 8 : 1478585-, 2018

6 Zhuang L, "Transmission of Severe Fever with Thrombocytopenia Syndrome Virus by Haemaphysalis longicornis Ticks, China" 24 : 868-871, 2018

7 Gondard M, "Ticks and Tick-Borne Pathogens of the Caribbean : Current Understanding and Future Directions for More Comprehensive Surveillance" 7 : 490-, 2017

8 Hubálek Z, "Tick-borne viruses in Europe" 111 : 9-36, 2012

9 Rudenko, N, "Tick-borne encephalitis virus specific RT-PCR- a rapid test for detection of the pathogen without viral RNA purification" 48 (48): 167-171, 2004

10 Danielova V, "Tick-borne encephalitis virus prevalence in Ixodes ricinus ticks collected in high risk habitats of the south-Bohemian region of the Czech Republic" 26 : 145-151, 2002

11 Bogovic P, "Tick-borne encephalitis : A review of epidemiology, clinical characteristics, and management" 3 : 430-441, 2015

12 Süss J, "Tick-borne encephalitis 2010 : Epidemiology, risk areas, and virus strains in Europe and Asia—An overview" 2 : 2-15, 2011

13 Lindquist L, "Tick-borne encephalitis" 371 : 1861-1871, 2008

14 Gritsun TS, "Tick-borne encephalitis" 57 : 129-146, 2003

15 Lehrer AT, "Tick-borne Encephalitis Vaccines" 3 : 2011

16 Shi J, "Tick-Borne Viruses" 33 : 21-43, 2018

17 Pulkkinen LIA, "Tick-Borne Encephalitis Virus : A Structural View" 10 : 350-, 2018

18 Yesilbag K, "Tick survey and detection of Crimean-Congo hemorrhagic fever virus in tick species from a non-endemic area, South Marmara region, Turkey" 60 : 253-261, 2012

19 Bell-Sakyi L, "Tick cell lines for study of Crimean-Congo hemorrhagic fever virus and other arboviruses" 12 : 769-781, 2012

20 Messina JP, "The global distribution of Crimean-Congo hemorrhagic fever" 109 : 503-513, 2015

21 Takahashi, T, "The first identification and retrospective study of Severe Fever Thrombocytopenia Syndrome in Japan" 209816-209827, 2014

22 Kunze, U, "The International Scientific Working Group on Tick-borne encephalitis(ISW TBE) : Review of 17 years of activity and committment" 7399-7404, 2015

23 Nuttall, PA, "The Encyclopaedia of Arthropod transmitted infections" CABI Publishing 2001

24 Mostafavi E, "Temporal modeling of Crimean-Congo hemorrhagic fever in eastern Iran" 17 : e524-e528, 2013

25 Chinikar S, "Surveillance and Laboratory Detection System of Crimean-Congo Haemorrhagic Fever in Iran" 55 : 200-204, 2008

26 Danes L, "Study of the possibility of preparing a vaccine against tick-borne encephalitis, using tissue culture methods. I. Propagation of tick-borne encephalitis virus in tissue cultures for vaccine preparation" 4 : 25-36, 1960

27 Füzik T, "Structure of tick-borne encephalitis virus and its neutralization by a monoclonal antibody" 9 : 436-, 2018

28 Scholte FEM, "Single-dose replicon particle vaccine provides complete protection against Crimean-Congo hemorrhagic fever virus in mice" 8 : 575-578, 2019

29 Dong F, "Single dose of a rVSV-based vaccine elicits complete protection against severe fever with thrombocytopenia syndrome virus" 4 : 5-, 2019

30 Hofmann H, "Severe fever with thrombocytopenia virus glycoproteins are targeted by neutralizing antibodies and can use DC-SIGN as a receptor for pH-dependent entry into human and animal cell lines" 87 : 4384-4394, 2013

31 Kim K-H, "Severe fever with thrombocytopenia syndrome, South Korea, 2012" 19 : 1892-1894, 2013

32 Yun S-M, "Severe fever with thrombocytopenia syndrome virus in ticks collected from humans, South Korea, 2013" 20 : 1358-1361, 2014

33 Choi Y, "Severe fever with thrombocytopenia syndrome phlebovirus non-structural protein activates TPL2 signalling pathway for viral immunopathogenesis" 4 : 429-437, 2019

34 Xie Y-T, "Severe fever with thrombocytopenia syndrome in China" 15 : 145-, 2015

35 Ecker M, "Sequence analysis and genetic classification of tick-borne encephalitis viruses from Europe and Asia" 80 : 179-185, 1999

36 Ebel GD, "SHORT REPORT : DURATION OF TICK ATTACHMENT REQUIRED FOR TRANSMISSION OF POWASSAN VIRUS BY DEER TICKS" 71 : 268-271, 2004

37 Rendi-Wagner P, "Risk and Prevention of Tick-borne Encephalitis in Travelers" 11 : 307-312, 2006

38 Reuben Kaufman W, "Rhipicephalus appendiculatus(Acari : Ixodidae) : dynamics of Thogoto virus infection in female ticks during feeding on guinea pigs" 104 : 20-25, 2003

39 Chitimia-Dobler L, "Repeated isolation of tick-borne encephalitis virus from adult Dermacentor reticulatus ticks in an endemic area in Germany" 12 : 90-90, 2019

40 Bergeron Ë, "Recovery of Recombinant Crimean Congo Hemorrhagic Fever Virus Reveals a Function for Non-structural Glycoproteins Cleavage by Furin" 11 : e1004879-, 2015

41 Grard G, "Re-emergence of Crimean-Congo hemorrhagic fever virus in Central Africa" 5 : e1350-, 2011

42 Růžek D, "Rapid subtyping of tick-borne encephalitis virus isolates using multiplex RT-PCR" 144 : 133-137, 2007

43 WHO, "R&D Blueprint on Crimean Congo Haemorrhagic fever (CCHF)" 2018

44 Donoso Mantke O, "Quality control assessment for the PCR diagnosis of tick-borne encephalitis virus infections" 38 : 73-77, 2007

45 Gondard M, "Prevalence of tick-borne viruses inIxodes ricinusassessed by high-throughput real-time PCR" 76 : 1-13, 2018

46 Pettersson JHO, "Prevalence of tick-borne encephalitis virus in Ixodes ricinus ticks in northern Europe with particular reference to Southern Sweden" 7 : 102-, 2014

47 Sadanandane C, "Prevalence and spatial distribution of Ixodid tick populations in the forest fringes of Western Ghats reported with human cases of Kyasanur forest disease and monkey deaths in South India" 75 : 135-142, 2018

48 Řeháček J, "Preparation of Tissue Cultures From the Tick Hyalomma dromedarii Koch" 2 : 161-164, 1965

49 Hu J, "Preliminary fast diagnosis of severe fever with thrombocytopenia syndrome with clinical and epidemiological parameters" 12 : e0180256-, 2017

50 Chinikar S, "Phylogenetic analysis in a recent controlled outbreak of Crimean-Congo haemorrhagic fever in the south of Iran, December 2008" 15 : 19720-, 2010

51 Mierzejewska, EJ, "Pathogens vectored by tick, Dermacanter reticulatus, in endemic regions and zones of expansion in Poland" 8 : 490-, 2015

52 Jin C, "Pathogenesis of emerging severe fever with thrombocytopenia syndrome virus in C57/BL6 mouse model" 109 : 10053-10058, 2012

53 Zivcec M, "Nucleocapsid protein-based vaccine provides protection in mice against lethal Crimean-Congo hemorrhagic fever virus challenge" 12 : e0006628-, 2018

54 Kim S, "Nonnoble-Metal-Based Plasmonic Nanomaterials : Recent Advances and Future Perspectives" 30 : 1704528-, 2018

55 Sun Y, "Nonmuscle myosin heavy chain IIA is a critical factor contributing to the efficiency of early infection of severe fever with thrombocytopenia syndrome virus" 88 : 237-248, 2014

56 Hee-Jin Ham, "No detection of severe Fever with thrombocytopenia syndrome virus from ixodid ticks collected in seoul" 대한기생충학ㆍ열대의학회 52 (52): 221-224, 2014

57 Li D, "Neutralizing antibodies to Severe Fever with Thrombocytopenia Syndrome Virus in general population, Shandong Province, China" 8 : 15401-, 2018

58 Beard CB, "Multistate infestation with the exotic disease–vector tick Haemaphysalis longicornis —United States, August 2017–September 2018" 67 : 1310-, 2018

59 Yun S-M, "Molecular genomic characterization of tick- and human-derived severe fever with thrombocytopenia syndrome virus isolates from South Korea" 11 : e0005893-, 2017

60 Yun S-M, "Molecular detection of severe fever with thrombocytopenia syndrome and tick-borne encephalitis viruses in ixodid ticks collected from vegetation, Republic of Korea, 2014" 7 : 970-978, 2016

61 Farhadpour F, "Molecular detection of Crimean-Congo haemorrhagic fever virus in ticks collected from infested livestock populations in a New Endemic Area, South of Iran" 21 : 340-347, 2016

62 Aziz TG, "Molecular and Serological Detection of Crimean-Congo Hemorrhagic Fever Virus in Sulaimani Province, Iraq" 04 : 36-42, 2016

63 Zivcec M, "Molecular Insights into Crimean-Congo Hemorrhagic Fever Virus" 8 : 106-, 2016

64 Jahfari S, "Molecular Detection of Tick-Borne Pathogens in Humans with Tick Bites and Erythema Migrans, in the Netherlands" 10 : e0005042-, 2016

65 Palomar AM, "Molecular (ticks) and serological (humans) study of Crimean-Congo hemorrhagic fever virus in the Iberian Peninsula, 2013–2015" 35 : 344-347, 2017

66 Dupuis AP 2nd, "Isolation of deer tick virus(Powassan virus, lineage II)from Ixodes scapularis and detection of antibody in vertebrate hosts sampled in the Hudson Valley, New York State" 6 : 185-, 2013

67 Jia Z, "Identification of a candidate standard strain of severe fever with thrombocytopenia syndrome virus for vaccine quality control in China using a cross-neutralization assay" 46 : 92-98, 2017

68 Gäumann R, "High"throughput procedure for tick surveys of tick-borne encephalitis virus and its application in a national surveillance study in Switzerland" 76 : 4241-4249, 2010

69 Sharifina, N, "Hard ticks (Ixodidae) and Crimean Congo Haemorrhagic Fever virus in South West of Iran" 5 (5): 178-181, 2015

70 Luo L-M, "Haemaphysalis longicornis Ticks as Reservoir and Vector of Severe Fever with Thrombocytopenia Syndrome Virus in China" 21 : 1770-1776, 2015

71 Yun S-M, "First Isolation of Severe Fever with Thrombocytopenia Syndrome Virus from Haemaphysalis longicornis Ticks Collected in Severe Fever with Thrombocytopenia Syndrome Outbreak Areas in the Republic of Korea" 16 : 66-70, 2016

72 Yoshii Y, "Fatty acid synthase is a key target in multiple essential tumor functions of prostate cancer : uptake of radiolabeled acetate as a predictor of the targeted therapy outcome" 8 : e64570-, 2013

73 Sun J, "Factors associated with Severe Fever with Thrombocytopenia Syndrome infection and fatal outcome" 6 : 33175-, 2016

74 Crowder CD, "Extraction of Total Nucleic Acids From Ticks for the Detection of Bacterial and Viral Pathogens" 47 : 89-94, 2010

75 Harvey E, "Extensive Diversity of RNA Viruses in Australian Ticks" 93 : e01358-e01318, 2019

76 Norbert John C. Robles, "Epidemiology of severe fever and thrombocytopenia syndrome virus infection and the need for therapeutics for the prevention" 대한백신학회 7 (7): 43-50, 2018

77 Jiang J-F, "Epidemiological, clinical, and laboratory characteristics of 48 cases of"Babesia venatorum"infection in China : a descriptive study" 15 : 196-203, 2015

78 Vescio FM, "Environmental correlates of Crimean-Congo haemorrhagic fever incidence in Bulgaria" 12 : 1116-, 2012

79 Matsuno K, "Emerging Infectious Diseases" Elsevier 2014

80 Ogden NH, "Effects of Climate and Climate Change on Vectors and Vector-Borne Diseases : Ticks Are Different" 32 : 646-656, 2016

81 Cyranoski D, "East Asia braces for surge in deadly tick-borne virus" 556 : 282-283, 2018

82 Taba P, "EAN consensus review on prevention, diagnosis and management of tick-borne encephalitis" 24 : 1214–e61-, 2017

83 Li S, "Duck Tembusu virus exhibits neurovirulence in BALB/c mice" 10 : 260-, 2013

84 Mazzola LT, "Diagnostic tests for Crimean-Congo haemorrhagic fever: a widespread tickborne disease" 4 : e001114-, 2019

85 Vanhomwegen J, "Diagnostic assays for Crimean-Congo hemorrhagic fever" 18 : 1958-1965, 2012

86 Holzmann H, "Diagnosis of tick-borne encephalitis" 21 : S36-S40, 2003

87 Salát J, "Development and testing of a new tick-borne encephalitis virus vaccine candidate for veterinary use" 36 : 7257-7261, 2018

88 Song P, "Deficient humoral responses and disrupted B-cell immunity are associated with fatal SFTSV infection" 9 : 3328-, 2018

89 Lozach P-Y, "DC-SIGN as a Receptor for Phleboviruses" 10 : 75-88, 2011

90 Maltezou HC, "Crimean–Congo hemorrhagic fever: Risk for emergence of new endemic foci in Europe?" 8 : 139-143, 2010

91 Zakhashvili K, "CrimeanCongo hemorrhagic fever in man, Republic of Georgia, 2009" 16 : 1326-1328, 2010

92 Karti SS, "Crimean-Congo hemorrhagic fever in Turkey" 10 : 1379-1384, 2004

93 Chinikar S, "Crimean-Congo hemorrhagic fever in Iran and neighboring countries" 47 : 110-114, 2010

94 Ansari H, "Crimean-Congo hemorrhagic fever and its relationship with climate factors in southeast Iran : a 13-year experience" 8 : 749-757, 2014

95 Sargianou M, "Crimean-Congo hemorrhagic fever : seroprevalence and risk factors among humans in Achaia, western Greece" 17 : e1160-e1165, 2013

96 Williams RJ, "Crimean-Congo haemorrhagic fever : a seroepidemiological and tick survey in the Sultanate of Oman" 5 : 99-106, 2000

97 Shayan, S, "Crimean-Congo haemorrhagic fever" 4 (4): 180-189, 2015

98 Ergönül Ø, "Crimean-Congo haemorrhagic fever" 6 : 203-214, 2006

99 Papa A, "Crimean-Congo Hemorrhagic Fever in Albania, 2001" 21 : 603-606, 2002

100 Yadav, PD, "Complete genome sequencing of Kaisodi virus isolated from ticks in India belonging to Phlebovirus genus, family Phenuiviridae" 10 : 23-33, 2019

101 Gilbert L, "Climate of origin affects tick (Ixodes ricinus) host-seeking behavior in response to temperature: implications for resilience to climate change?" 4 : 1186-1198, 2014

102 Zhang L, "Characterization of severe fever with thrombocytopenia syndrome in rural regions of Zhejiang, China" 9 : e111127-, 2014

103 Tani H, "Characterization of Glycoprotein-Mediated Entry of Severe Fever with Thrombocytopenia Syndrome Virus" 90 : 5292-5301, 2016

104 Atrasheuskaya AV, "Changes in immune parameters and their correction in human cases of tick-borne encephalitis" 131 : 148-154, 2003

105 Hay J, "Biosurveillance in Central Asia : Successes and Challenges of Tick-Borne Disease Research in Kazakhstan and Kyrgyzstan" 4 : 4-, 2016

106 Kovalev SY, "Baltic lineage of tick-borne encephalitis virus : A putative evolutionary pathway" 7 : 1209-1215, 2016

107 Samudzi RR, "Bacterial expression of Crimean-Congo hemorrhagic fever virus nucleoprotein and its evaluation as a diagnostic reagent in an indirect ELISA" 179 : 70-76, 2012

108 Devignot S, "A virus-like particle system identifies the endonuclease domain of Crimean-Congo hemorrhagic fever virus" 89 : 5957-5967, 2015

109 McMullan, LK, "A new phlebovirus associated with severe febrile illness in Missouri" 367 : 834-841, 2012

110 Tagliabue G, "A label-free immunoassay for Flavivirus detection by the Reflective Phantom Interface technology" 492 : 558-564, 2017

111 Wang Z-D, "A New Segmented Virus Associated with Human Febrile Illness in China" 380 : 2116-2125, 2019

112 Walker PJ, "A Global Genomic Characterization of Nairoviruses Identifies Nine Discrete Genogroups with Distinctive Structural Characteristics and Host-Vector Associations" 94 : 1107-1122, 2016

113 Dowall SD, "A Crimean-Congo hemorrhagic fever(CCHF)viral vaccine expressing nucleoprotein is immunogenic but fails to confer protection against lethal disease" 12 : 519-527, 2016