국산 특수방수천으로 만든 침구카바 사용이 알레르기 면역반응과 천식 증상에 미치는 영향

다국어 초록 (Multilingual Abstract)

To evaluate the special bedding cover on the allergic immune response and the clinical symptoms in house dust mite -sensitive asthmatics, we studied the protective effect of special vapour-permeable waterproof fabric bedding cover made of Korean textile (HIPORA, Kolon, Seoul, Korea). 20 mite sensitive asthmatics were randomized either to a conventional bedding cover group(n= 10) or to special bedding cover group(n=10) using a vapour-permeable water proof fabric bedding cover. The dusts of mattresses, pillows and quilt,s were sampled by vacuum cleaner from June, 1993 to December, 1993. Dust samples were coded, weighed and analyzed with blind method. Amounts of Group I major allergens (Der f I, Der p I ) of house dust, mites in dust samples were measured by ELISA. Total IgE, skin reactivity, specific IgE to t.wo house dust mites(D. pteronyssinus, D. farinae), total eosinophil count in peripheral blood were measured at the beginning, at the 3 months and at. The 6 months of the st,udy. Asthmat,ic symptoms and peak expiratory flow rate were evaluated for 7days after dust collection of each month. 1. The amount, of dust collect.ed was reduced in both groups, and the reduction was significant only in the special bedding cover group(p <.001). 2. Der p I and Der f I were coexisted in the house dusts, and the mean amounts were 2.39 ug of Der p I / gram of dust and 6.78 ug of Der f I /gram of dust. 3. The total amounts of group I allergens( Der f I and Der p I ) reached their peak in August in the conventional bedding cover group (mean 12.72 ug/gm of dust) and September in the special bedding cover group (mean 18.84 ug/gm of dust). 4. There was no significant difference in the amounts and changing patterns of group I allergen of house dust mites in both groups. 5. There was no significant, difference in the changes of allergic immune responses such as skin reactivity, total and mite-specific IgE antibodies and total eosinophil count in both groups. But in both groups changing patterns of mite specific IgE antibodies were consistent with changes in mite allergen amounts in dust. 6. There was no significant difference in symptom scores and pulmonary function test results in both groups. In conclusion, use of special vapour permeable water proof fabric bedding cover made of Korean textile(HIPORA) in mite sensitive asthmatics could not decrease house dust mite allergen in bedding.