파킨슨 병 환자에서의 혈청 Norepinephrine치와 혈압 변화 = Serum Norepinephrine and Alternations of Blood Pressure in Parkinsonian Patients

다국어 초록 (Multilingual Abstract)

Parkinsonian patients often, in addition to motor symptoms and signs, have autonomic nervous system dysfunction such as constipation, impotence and diminished sweating. Among the symptoms of autonomic failure, alternations in blood pressure regulation, such as orthostatic hypotension, were sensitive.
In this study, clinical informations, blood pressure, serum dopamine, norepinephrine and/or HVA, and urinary VMA have been investigated in 12 untreated Parkinsonian patients, 7 treated Parkinsonian patients with L-dopa therapy, and in 8 age matched controls. The mean age at onset of the patients was 57.25±11.69 years, a figure similar to those reported in other series, and the disease occurred more often in females than in males. The patients were classified according to Hoehn-Yahr stage into : stage Ⅰ (1 case), stage Ⅱ (7 cases), stage Ⅲ (15 cases), stage Ⅳ (6 cases).
Of the various autonomic dysfunctional manifestations of Parkinson's disease, considerable problems also were constipation, other gastrointestinal discomforts, dizziness and hypotension.
No significant relationship was found in the Parkinsonian groups and control between serum norepinephrine and HVA, urinary VMA, and alternations of blood pressure, but in the Parkinsonian patients with L-dopa therapy it showed higher levels of serum dopamine and HVA.