有機및 無機發癌物質의 化學發癌性에 對한 分子軌道論的 硏究 = Study on M.O. theory for Chemical Carcinogenesis of Organic and Inorganic Carcinogens

다국어 초록 (Multilingual Abstract)

The formation of a loosely bound molecular complex between chemical carcinogen and a cellular component was showned to be first step of Carcinogenesis.
Assuming that some positions in the carcinogenic molecule play an important role in forming the molecular complex, the electron distribution of several organic precarcinogens and their metabolites was examined by means of HMO method.
The results showed that the ability of accepting electrons at the two carbons of K-region and the atom of L-region in proximity of K-region increases with the proceeding of the metabolism that is in order of precarcinogen, proximate carcingen, ultimate carcinogen charged positively.
Accordingly, the first step of Carcinogenesis is considered to be essential the formation of a positive ion as the result of metabolism.
From this point of view, an attempt has been made to account for the carcinogenic activity of inorganic elements.
It has been found as the result of comparison with experiments that a quantity named "excess polarizing strength" is qualified as good measure to predict the carcinogenic activity of inorganic elements.
All elements which is above 0.22 in the value of "excess polarizing strength" have carcinogenic activity.
The unified interpretation of the carcinogenicity of both organic compounds and inorganic elements may be possible on the assumption that the formation of molecular complex between a carcinogen and a cellular component is essential to the formation in the metabolism of positive ion in the body as an ultimate carcinogen.