The author has investigated the appearance of sudanophilic materials in various intraocular tissues and ascending aorta of the cholesterol fed, adrenalin injected and cortisone administered rabbits. The author has also studied the relationship between...
The author has investigated the appearance of sudanophilic materials in various intraocular tissues and ascending aorta of the cholesterol fed, adrenalin injected and cortisone administered rabbits. The author has also studied the relationship between the limitation of exercise and the results of the sudanophilic deposit.
The results obtained are as follows;
1) Sudanophilic deposits are observed in some of intraocular tissues not only in the group of cholesterol fed rabbits but also in the adrenalin injected group and the group in which massive dosis of cortisone was given.
2) The deposit are most markedly seen in the group of cholesterol fed least in the adrenalin injected group.
3) In the cholesterol fed group, the deposits are detected in uvea, sclera, peripheral cornea, and chamber angle in the order of decreasing intensity.
4) In the groups in which adrenalin and cortisone are intramuscularly injected, no deposit is seen in the intraocular tissues except for the uveal tract. No determination is done if the prolongation of the experimental period makes any change of this finding.
5) As far as uveal tissue is concerned, iris is the tissue in which the least sudanophilic materials are deposited.
6) Specific findings are fatty plaques in the posterior surface of iris in the cholesterol fed group and lipoidosis in iris vessels in the cortisone given group.
7) Although the lipid deposits of aortic intima and lipoidosis of intraocular tissues appear almost simultaneously, intraocular vascular changes are delayed in their appearance in comparison with the aortic changes.
8) Limitation of exercise augmented sudanophilic deposits, thus making one postulate that it affects the lipid metabolism.