항응고제 코팅기술을 이용한 PVC와 실리콘 제품의 고기능성 흡입 배액용구의 개발 = Development of Advanced Suction Drainage Device of PVC and Silicone with Anticoagulant Coating Technology

다국어 초록 (Multilingual Abstract)

Advanced anticoagulant suction drainage was prepared by anticoagulant coating with the hydrophobic multicomponent heparin conjugates, and named as MCK-Hepafilm (15K). The coating surface was analyzed by the staining test of azure-A and scanning electron microscope (SEM), which shows excellent coating effect on silicone as well as PVC. The coating condition of silicone tube was optimized to 3.0 wt% concentration of coating solution and the solvent casting temperature to 35 oC. In vitro anticoagulant effect is confirmed by observation of platelet adhesion, blood coagulation and adhesion of bacteria. Platelet adhesion on coating surface of PVC and silicone drainage tube was remarkably reduced, and completely prevented from whole blood clots of rabbit. The adhered number of Escherichia coil (E. coil) bacteria on coated surface of PVC drainage tube was reduced with 7.2?.0 CFU/cm2 as compared to the non-coated surface of 10.1?.2 CFU/cm2. Rabbit experiment has been carried out for the MCK-Hepafilm (15K) coated suction drainage device. The efficacy of the MCK-Hepafilm coat was examined by measuring the debris weight forming clogging in the tube (MCK-Hepafilm coated & uncoated) and analyzing the change in blood flow pressure through it, over a period of time, after insertion in the abdomen of the rabbit. In the coating tube, the internal resistance of PVC was reduced, and also the debris weight of silicone was reduced to 315.5?.4 mg as compared with non-coated 555.7?0.6 mg. The obtained results indicate the effectiveness of this MCK-Hepafilm (15K) coating technology for blood contacting medical devices including suction drainage devices in improving their hemocompatibility.

참고문헌 (Reference)

1 "？Polyurethane surface modified by amphiphilic polymers Effects on protein adsorption" 307-315, 2000

2 "？Heparin coating reduces encrustation of ureteral stent" 507-510, 2002

3 "？Fluid flow during percutaneous drainage procedures an in vitro study of the effects of fluid viscosity" 165-169, 1993

4 "？Development of chitosan/polyethylene vinyl acetate co-matrix Controlled release of aspirin-heparin for preventing cadiovascular thrombosis" 375-381, 1997

5 "？Clogging of drainage catheters quantitative and longitudinal assessment by monitoring intracatheter pressure in catheters and rabbits" 833-838, 2003

6 "An Introduction to Materials in Medicine" Academic Press ？ (？): 297-308, 1997

7 "-heparin hydrogels as sensor catheter membrane" 63-70, 1991