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      (The) Risk of aggravation of diabetic foot according to climatic and air quality factors in South Korea : a nationwide population-based study = 대한민국의 기상요소 및 대기질에 따른 당뇨발 악화의 위험도 연구: 인구 기반 전국 연구

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      https://www.riss.kr/link?id=T16851416

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      다국어 초록 (Multilingual Abstract)

      Purpose: This study aims to examine the association between the occurrence of diabetic foot and climatic factors (i.e., temperature, humidity, and diurnal temperature range) and atmospheric particulate matter.

      Methods: Open data were collected to conduct a big data study. Patient information was gathered from the National Health Insurance Service, temperature and humidity information was collected from the Korea Meteorological Administration's Weather Floor portal, and the National Institute of Environmental Science's air quality data was used. The lag period from weather and air quality changes to the actual amputation operation was calculated for each factor. The frequency of diabetic foot amputation in each region was identified and analyzed using a distributed lag non-linear model.

      Results: The relative risk was highly correlated with increasing diurnal temperature range in the capital area areas and increasing relative humidity in low-latitude regions. SO2 and CO were highest in Gangwon-do. NO2 was highest in Chungcheongnam-do, and O3 was highest in the Jeju-do. High PM10 was observed in Gangwon-do, and PM2.5 was high in Gangwon-do and Gyeongsangbuk-do.

      Conclusion: The risk of diabetic foot amputation associated with the diurnal temperature range was high in the capital area, and the risk associated with relative humidity was high in the low-latitude regions. The risk associated with atmospheric particulate matter also differed from region to region.
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      Purpose: This study aims to examine the association between the occurrence of diabetic foot and climatic factors (i.e., temperature, humidity, and diurnal temperature range) and atmospheric particulate matter. Methods: Open data were collected to con...

      Purpose: This study aims to examine the association between the occurrence of diabetic foot and climatic factors (i.e., temperature, humidity, and diurnal temperature range) and atmospheric particulate matter.

      Methods: Open data were collected to conduct a big data study. Patient information was gathered from the National Health Insurance Service, temperature and humidity information was collected from the Korea Meteorological Administration's Weather Floor portal, and the National Institute of Environmental Science's air quality data was used. The lag period from weather and air quality changes to the actual amputation operation was calculated for each factor. The frequency of diabetic foot amputation in each region was identified and analyzed using a distributed lag non-linear model.

      Results: The relative risk was highly correlated with increasing diurnal temperature range in the capital area areas and increasing relative humidity in low-latitude regions. SO2 and CO were highest in Gangwon-do. NO2 was highest in Chungcheongnam-do, and O3 was highest in the Jeju-do. High PM10 was observed in Gangwon-do, and PM2.5 was high in Gangwon-do and Gyeongsangbuk-do.

      Conclusion: The risk of diabetic foot amputation associated with the diurnal temperature range was high in the capital area, and the risk associated with relative humidity was high in the low-latitude regions. The risk associated with atmospheric particulate matter also differed from region to region.

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      국문 초록 (Abstract)

      목적: 기후 요소 온도 , 습도 , 일교차 ), 대기질 미세먼지 요소와 당뇨발 발생 사이의 연관성을 확인한다

      방법: 대규모 자료 연구를 시행하기 위해 개방형 자료를 수집하였다 . 환자정보는 국민건강보험공단 , 온도 및 습도는 기상청 날씨마루 포털 , 대기질은 에어코리아 포털 및 국립 환경 과학원 자료를 이용했다 . 기상 변화 및 대기질 변화가 실제 절단 시술까지 진행되는데 소요되는 지연기간을 각 인자별로 산정하였으며 , 각 지역별 당뇨발 절단 빈도 파악 후 istributed lag non linear model 을 통해 분석하였다

      결과: 상대위험도는 수도권 지역에서 일 교차가 증가할수록 , 저위도 지역에 서 상대 습도 증가할수록 높은 연관성이 나타났다 . SO 2 와 CO 는 강원 . NO 2는 충남 , O 3 는 제주 지역에서 가장 높았다 . PM10 는 강원 , PM2.5 는 강원과
      경북지역에서 높았다

      결론: 일교차는 수도권 , 상대 습도는 저위도 지역에서 당뇨발 절단의 위험이 높게 나타났다 . 대기질 미세먼지 요소도 지역마다 달랐다
      번역하기

      목적: 기후 요소 온도 , 습도 , 일교차 ), 대기질 미세먼지 요소와 당뇨발 발생 사이의 연관성을 확인한다 방법: 대규모 자료 연구를 시행하기 위해 개방형 자료를 수집하였다 . 환자정보는 ...

      목적: 기후 요소 온도 , 습도 , 일교차 ), 대기질 미세먼지 요소와 당뇨발 발생 사이의 연관성을 확인한다

      방법: 대규모 자료 연구를 시행하기 위해 개방형 자료를 수집하였다 . 환자정보는 국민건강보험공단 , 온도 및 습도는 기상청 날씨마루 포털 , 대기질은 에어코리아 포털 및 국립 환경 과학원 자료를 이용했다 . 기상 변화 및 대기질 변화가 실제 절단 시술까지 진행되는데 소요되는 지연기간을 각 인자별로 산정하였으며 , 각 지역별 당뇨발 절단 빈도 파악 후 istributed lag non linear model 을 통해 분석하였다

      결과: 상대위험도는 수도권 지역에서 일 교차가 증가할수록 , 저위도 지역에 서 상대 습도 증가할수록 높은 연관성이 나타났다 . SO 2 와 CO 는 강원 . NO 2는 충남 , O 3 는 제주 지역에서 가장 높았다 . PM10 는 강원 , PM2.5 는 강원과
      경북지역에서 높았다

      결론: 일교차는 수도권 , 상대 습도는 저위도 지역에서 당뇨발 절단의 위험이 높게 나타났다 . 대기질 미세먼지 요소도 지역마다 달랐다

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      목차 (Table of Contents)

      • Ⅰ. Introduction ······················································· 10
      • 1. Introduction 1 ····················································· 10
      • 2. Introduction 2 ····················································· 11
      • Ⅱ. Study Purpose ···················································· 12
      • 1. Study Purpose 1 ·················································· 12
      • Ⅰ. Introduction ······················································· 10
      • 1. Introduction 1 ····················································· 10
      • 2. Introduction 2 ····················································· 11
      • Ⅱ. Study Purpose ···················································· 12
      • 1. Study Purpose 1 ·················································· 12
      • Ⅲ. Subjects and Methods ······································· 13
      • 1. Subjects 1 ··························································· 13
      • 2. Subjects 2 ··························································· 14
      • Ⅵ. Results ····························································· 18
      • 1. Results 1 ···························································· 18
      • 2. Results 2 ···························································· 20
      • Ⅴ. Discussion ························································ 29
      • 1. Discussion 1 ······················································ 29
      • 2. Discussion 2 ······················································ 31
      • 3. Discussion 3 ······················································ 34
      • Ⅵ. Conclusion ······················································· 35
      • References ···························································· 36
      • Appendix ······························································ 39
      • Acknowledgment ················································· 50
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      참고문헌 (Reference) 논문관계도

      1 Dourakis SP, Vallianou NG, Stratigou T, Kounatidis D, Geladari EV, Geladari CV, "Diabetes mellitus in the era of climate change", 47(4):101205, 2021

      2 Kang ES, Won KC, Won JC, Lee JH, Kim JH, Kim DJ, "Diabetes Fact Sheet in Korea, 2016: An Appraisal of Current Status", 42(5):415-24, 2018

      3 Andersen ZJ, Raaschou-Nielsen O, Loft S., Ketzel M, Jensen SS, Hvidberg M, "Diabetes incidence and long-term exposure to air pollution: a cohort study", 35(1):92-8, 2012

      4 Cakmak, S., Vidal, C. B., Rubio, M. A, Dales, R. E., "Air pollution and hospitalization for acute complications of diabetes in Chile", 46: 1-5, 2012

      5 Janghorbani M, Momeni F, Mansourian M., "Systematic review and metaanalysis of air pollution exposure and risk of diabetes", 29:231-42, 2014

      6 Almendra R, Santana P., Melo M, Gaspar RA, "Seasonal pattern of amputations in diabetic patients between 2000 and 2015 in Portugal", 28(Suppl_4):cky214.156, 2018

      7 Cho JH, Yang HJ, Kim S, Kim JH, Kim J, Chun DI, "Epidemiology and Burden of Diabetic Foot Ulcer and Peripheral Arterial Disease in Korea", 8(5):748, 2019

      8 Chung CH, Min KW,, Kim J, Kim H, Kim H, Kim DJ, "Current status of diabetic foot in Korean patients using national health insurance database", 30:372-6, 2006

      9 Honda T, Suh H., Pun VC, Manjourides J, "Associations between long-term exposure to air pollution, glycosylated hemoglobin and diabetes", 220(7):1124-32, 2017

      10 Cho JH, Won SH, Park IK, Chun DI, "Relationship between the Diurnal Temperature Range and Wound Healing of Diabetic Foot: Animal Study", 24(4):142-7, 2020

      1 Dourakis SP, Vallianou NG, Stratigou T, Kounatidis D, Geladari EV, Geladari CV, "Diabetes mellitus in the era of climate change", 47(4):101205, 2021

      2 Kang ES, Won KC, Won JC, Lee JH, Kim JH, Kim DJ, "Diabetes Fact Sheet in Korea, 2016: An Appraisal of Current Status", 42(5):415-24, 2018

      3 Andersen ZJ, Raaschou-Nielsen O, Loft S., Ketzel M, Jensen SS, Hvidberg M, "Diabetes incidence and long-term exposure to air pollution: a cohort study", 35(1):92-8, 2012

      4 Cakmak, S., Vidal, C. B., Rubio, M. A, Dales, R. E., "Air pollution and hospitalization for acute complications of diabetes in Chile", 46: 1-5, 2012

      5 Janghorbani M, Momeni F, Mansourian M., "Systematic review and metaanalysis of air pollution exposure and risk of diabetes", 29:231-42, 2014

      6 Almendra R, Santana P., Melo M, Gaspar RA, "Seasonal pattern of amputations in diabetic patients between 2000 and 2015 in Portugal", 28(Suppl_4):cky214.156, 2018

      7 Cho JH, Yang HJ, Kim S, Kim JH, Kim J, Chun DI, "Epidemiology and Burden of Diabetic Foot Ulcer and Peripheral Arterial Disease in Korea", 8(5):748, 2019

      8 Chung CH, Min KW,, Kim J, Kim H, Kim H, Kim DJ, "Current status of diabetic foot in Korean patients using national health insurance database", 30:372-6, 2006

      9 Honda T, Suh H., Pun VC, Manjourides J, "Associations between long-term exposure to air pollution, glycosylated hemoglobin and diabetes", 220(7):1124-32, 2017

      10 Cho JH, Won SH, Park IK, Chun DI, "Relationship between the Diurnal Temperature Range and Wound Healing of Diabetic Foot: Animal Study", 24(4):142-7, 2020

      11 Chun DI, Lee J, Kim K, Kang EM, Jeon YJ,, Chung HJ, "Trend and Seasonality of Diabetic Foot Amputation in South Korea: A Population-Based Nationwide Study", 19(7):4111, 2022

      12 Jung Y-R, Shin C-S, Lee K-B, Kim K-T, Kim J-K, "A Report on Diabetic Foot and Amputation from the Korean Health Insurance Review & Assessment Service Data", 21:66-9, 2017

      13 Alderete TL, Wild LE, Patterson WB, Naik NN, Bailey MJ, "Exposure to air pollutants and the gut microbiota: a potential link between exposure, obesity, and type 2 diabetes", 11(5):1188-202, 2020

      14 Cho JH Moon SD, Park SA, Lee SH, Ko SH, Jang SA,, "Incidence of diabetic foot and associated risk factors in Type 2 diabetic patients: a five-year observational study", 33:315-23, 2009

      15 Chai G., Zhang K, Zhang J, Zhai G, "Impact of diurnal temperature range on hospital admissions for cerebrovascular disease among farmers in Northwest China", 12(1):15368, 2022

      16 Bucher HC, Schindler C, Künzli N., Hoffmann B, Hemkens LG, Eze IC, "Association between ambient air pollution and diabetes mellitus in Europe and North America: systematic review and meta-analysis", 123(5):381-9, 2015

      17 Chun DI, Won SH, Min TH,, Lee J, Jeon YJ, Chung HJ, "Diurnal Temperature Ranges in Relation to Lower Limb Amputation Rate of Diabetic Foot in South Korea: A Population Based Nationwide Study", 18(17):9191, 2021

      18 Brüske I, Thiering E, Sugiri D., Markevych I, Kratzsch J, Fuertes E, "Associations of residential long-term air pollution exposures and satellite-derived greenness with insulin resistance in German adolescents", 124(8):1291-8, 2016

      19 Brandt J, Sørensen M, Poulsen AH, Hvidtfeldt UA, Frohn LM,, Christensen JH, "Effects of Sociodemographic Characteristics, Comorbidity, and Coexposures on the Association between Air Pollution and Type 2 Diabetes: A Nationwide Cohort Study", 131(2):027008, 2023

      20 Cho JH, Yang HJ, Kim S, Kim JH, Kim J, Chun DI, "Trends in lower limb amputation in patients with diabetic foot based on vascular intervention of peripheral arterial disease in Korea: A population-based nationwide study", 34(26):e178, 2019

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