<P><B>Summary</B></P><P><B>Objective</B></P><P>Disruption of the vascular supply to the bone and subsequent hypoxia has been implicated in the pathogenesis of osteonecrosis (ON) of the femoral head...
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https://www.riss.kr/link?id=A107415259
2007
-
HIF1α ; Osteonecrosis ; SNP ; Polymorphism ; Hypoxia ; Femoral head
SCI,SCIE,SCOPUS
학술저널
688-694(7쪽)
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
<P><B>Summary</B></P><P><B>Objective</B></P><P>Disruption of the vascular supply to the bone and subsequent hypoxia has been implicated in the pathogenesis of osteonecrosis (ON) of the femoral head...
<P><B>Summary</B></P><P><B>Objective</B></P><P>Disruption of the vascular supply to the bone and subsequent hypoxia has been implicated in the pathogenesis of osteonecrosis (ON) of the femoral head (ONFH). To evaluate the genetic effect of <I>HIF1α</I>, a key transcription factor in controlling hypoxia condition, on ONFH, we analyzed <I>HIF1α</I> polymorphism and its genetic association with ONFH.</P><P><B>Methods</B></P><P>We directly sequenced the <I>HIF1α</I> gene in 24 Korean individuals and identified four sequence variants. Four polymorphisms (−2755C>A, +41224T>C, +45319C>T, +51610C>T) were genotyped in ONFH (<I>n</I>=384). ONFH patients were divided into three subgroups based on etiological factors: idiopathic (129 cases), steroid (59 cases) and alcohol (196 cases) ON groups.</P><P><B>Results</B></P><P>We found that the allele frequency of −2755C>A and the genotype frequencies of +41224T>C and +51610C>T were significantly associated with idiopathic ONFH in men (<I>P</I>=0.0409, 0.0113, 0.0269, respectively). In addition, haplotype (CTCC) of <I>HIF1α</I> was also significantly associated with idiopathic ONFH in men (<I>P</I>=0.017).</P><P><B>Conclusions</B></P><P>We found that <I>HIF1α</I> polymorphisms are associated with idiopathic ONFH in men. These results suggest that variations in <I>HIF1α</I> may play an important role in the pathogenesis and risk factor for ONFH.</P>