POSTER PRESENTATION 1: Resuscitation/Airway Management : PS1-3 ; Acute Physiologic and Chronic Health Examination II and Sequential Organ Failure Assessment Scores for The Prediction of Outcomes in Out-of-Hospital Cardiac Arrest Patients Treated with Ther = POSTER PRESENTATION 1: Resuscitation/Airway Management : PS1-3 ; Acute Physiologic and Chronic Health Examination II and Sequential Organ Failure Assessment Scores for The Prediction of Outcomes in Out-of-Hospital Cardiac Arrest Patients Treated with Ther

다국어 초록 (Multilingual Abstract)

The aim of this study was to assess the relationship between the Acute Physiologic and Chronic Health Examination (APACHE) II and Sequential Organ Failure Assessment (SOFA) scores and the outcomes in post-cardiac arrest patients treated with therapeutic hypothermia (TH). Out-of-hospital cardiac arrest (OHCA) survivors treated with TH between January 2010 and December 2012 were retrospectively evaluated. We captured all components of the APACHE II and SOFA scores over the first 48 hours (48-h) after intensive care unit (ICU) admission (0-h). The primary outcome measure was in-hospital mortality and secondary outcome measure was neurologic outcome at hospital discharge. Receiver-operating characteristic (ROC) and logistic regression analysis were used to determine the predictability of outcomes with serial APACHE II and SOFA scores. A total of 138 patients were enrolled in the study. At the time of hospital discharge, 81 patients (58.7%) survived and 47 patients (34.1%) had a good neurologic outcome (cerebral performance category, CPC: 1-2). The area under the curve (AUC) for only APACHE II score at 0-h to predict in-hospital mortality and poor neurologic outcome (CPC: 3-5) was more than 0.7 and that for each SOFA score from 0-h to 48-h to predict in-hospital mortality and poor neurologic outcome was less than 0.7. Odds ratios (OR) to determine the associations between APACHE II scores from 0-h to 48-h and in-hospital mortality were 1.12 (95% confidence interval [CI], 1.03-1.23), 1.13 (95% CI, 1.04-1.23), and 1.18 (95% CI, 1.07-1.30) and those to determine the associations between APACHE II scores from 0-h to 48-h and poor neurologic outcome were 1.15 (1.05-1.25), 1.14 (1.05-1.24), and 1.18 (1.08-1.29). APACHE II but not SOFA score at ICU admission is a modest predictor of in-hospital mortality and poor neurologic outcome at hospital discharge for patients undergone TH after return of spontaneous circulation (ROSC) following OHCA.