본 연구는 MRI 조영제나 새로운 생리활성 물질을 개발키 위해 paraformaldehyde와 hypophosphorous acid를 아미노산인 glycine 혹은 glutamic acid와 함께 반응시켜 3,7-dihydroxy-3,7-dioxoperhydro-1,5,3,7-diazadiphos-phocme...
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https://www.riss.kr/link?id=A103837188
조승환 (한미제약) ; 송주현 (동아대학교) ; 이도훈 (동아대학교) ; 이용균 (동아대학교) ; 박유미 (동아대학교) ; 최순규 (동아대학교) ; 한정태 (영동대학교) ; 정대일 (동아대학교) ; Cho, Seung-Hwan ; Song, Ju-Hyun ; Lee, Do-Hun ; Lee, Yong-Gyun ; Park, Yu-Mi ; Choi, Soon-Kyu ; Hahn, Jung-Tai ; Jung, Dai-Il
2007
English
Contrasting agent ; esterfication ; amino acid ; 1 ; 5 ; 3 ; 7-diazadiphosphocine-1 ; 5-dicarboxylic
KCI등재
학술저널
910-914(5쪽)
0
0
상세조회0
다운로드국문 초록 (Abstract)
본 연구는 MRI 조영제나 새로운 생리활성 물질을 개발키 위해 paraformaldehyde와 hypophosphorous acid를 아미노산인 glycine 혹은 glutamic acid와 함께 반응시켜 3,7-dihydroxy-3,7-dioxoperhydro-1,5,3,7-diazadiphos-phocme...
본 연구는 MRI 조영제나 새로운 생리활성 물질을 개발키 위해 paraformaldehyde와 hypophosphorous acid를 아미노산인 glycine 혹은 glutamic acid와 함께 반응시켜 3,7-dihydroxy-3,7-dioxoperhydro-1,5,3,7-diazadiphos-phocme-1,5-diacetic acid 1 와 3,7-dihydrexy-3,7-dioxoperhydre-1,5,3,7-diazadiphos-phocme-1,5-di- (2-glutaric acid)3을 합성하였다. 그러나 aspartic acid에 의한 2-[5-(1,2-dicarboxy-ethyl)-3,7-dihydroxy-3,7-dioxo-315.715-[1,5,3,7]diazadiphosphocan-1-yl]-succinic acid 2는 얻지 못했다. 합성 된 3,7-dihydroxy-3,7-dioxoperhydro-1,5,3,7-dia-zadiphosphocine-1,5-diacetic acid 1을 산 촉매에 의한 에스테르화반응시켜 화합물 3,7-dihydroxy-3,7-dioxoper-hydro-1,5,3,7-diazadiphosphocine-1,5-diacetic acid methyl ester 4, 3,7-dihydroxy-3,7-dioxoperhydro-1,5,3,7-dia-zadiphosphocine-1,5-diacetic acid ethyl ester 5, 그리고 3,7-dihyoxy-3,74dioxoperhyo-1,5,3,7-diazadiphosphocine-1,5-diacetic acid propyl ester 6을 합성하였다. 계속해서 다양한 반응을 통해 새로운 화합물을 합성할 것이며 생리활성검색도 실시할 예정이다.
다국어 초록 (Multilingual Abstract)
In order to synthesize new bioactive compounds and contrasting agents, reactions of glycine and glutamic acid as an animo acid with paraformaldehyde and hypophosphorous acid were executed. Products are 3,7-dihydroxy-3,7-dioxoperhydro-1,5,3,7-diazadiph...
In order to synthesize new bioactive compounds and contrasting agents, reactions of glycine and glutamic acid as an animo acid with paraformaldehyde and hypophosphorous acid were executed. Products are 3,7-dihydroxy-3,7-dioxoperhydro-1,5,3,7-diazadiphosphocine-1,5-diacetic acid 1 and 3,7-dihydroxy-3,7- dioxoperhydre-1,5,3,7-diazadiphosphocine-1,5-di-(2-glu taric acid) 3. 2-[5-(1,2-Dicarboxyethyl)-3,7-dihydroxy-3,7-dioxo-315.715-[1,5,3,7] diazadiphosphocan-1-yl]-succinic acid 2 by using aspartic acid was not obtained. Esterification of 3,7- dihydroxy-3,7-dioxoperkydro-1,5,3,7-diaza-diphosphocine-1,5-diacetic acid 1 by treatment of methanol, ethanol, and propanol were executed. 3,7-Dihydroxy-3,7-dioxoperhydro-1,5,3,7-diazadiphosphocine-1,5-diacetic acid methyl ester 4, 3.7-dihydroxy-3,7-dioxoperhydro-1,5,3,f-diazadiphosphocine-1.5-diacetic acid ethyl ester 5, and 3,7-dihydroxy-3,7-dioxoperhydro-1,5,3,7-diazadiphosphocine-1,5-diacetic acid propyl ester 6 were respectively synthesized in good yields. Continuously, we will try synthesis of novel compounds and evaluation of biological activity.
참고문헌 (Reference)
1 Tatchell, A. R., "Vogel's Textbook of Practical Organic Chemistry, 4th eds." The Chaucer Press 264-319, 1978
2 Bodern, N. R., "The design and synthesis of simple molecular tethers for binding biomembranes to a gold surface" 53 : 10939-10952, 1997
3 Lattuada, L, "Synthesis of Gd-DTPA- cholesterol: a new lipophilic gadolinium complex as a potential MRI contrast agent" 44 : 3893-3895, 2003
4 Vu, H., "Synthesis and Properties of Cholesteryl-Modified Triple-Helix Forming Oligonucleotides Containing a Triglycyl Linker" 5 : 666-668, 1994
5 Arnold, P., "Superparamagnetic iron oxide (SPIO) enhancement in the cirrhotic liver: a comparison of two doses of ferumoxides in patients with advanced disease" 21 : 695-700, 2003
6 Akiyoshi, K., "Stabilization of Insulin upon Supramolecular Complexation with Hydrophobized Polysaccharide Nanoparticle" 8 : 707-708, 1995
7 Lauffer, R. B., "Preparation and water relaxation properties of proteins labeled with paramagnetic metal chelates" 3 : 11-16, 1985
8 Ladd, D. L., "Polymeric Gadolinium Chelate Magnetic Resonance Imaging Contrast Agents: Design, Synthesis and Properties" 10 : 361-370, 1999
9 Thunus, L., "Overview of transition metal and lanthanide complexes as diagnostic tools" 184 : 125-155, 1999
10 Aime, S., "One-step synthesis of a new eight-membered cyclic ligand from glycine, formaldehyde and hypophosphorous acid" 43 : 8387-8389, 2002
1 Tatchell, A. R., "Vogel's Textbook of Practical Organic Chemistry, 4th eds." The Chaucer Press 264-319, 1978
2 Bodern, N. R., "The design and synthesis of simple molecular tethers for binding biomembranes to a gold surface" 53 : 10939-10952, 1997
3 Lattuada, L, "Synthesis of Gd-DTPA- cholesterol: a new lipophilic gadolinium complex as a potential MRI contrast agent" 44 : 3893-3895, 2003
4 Vu, H., "Synthesis and Properties of Cholesteryl-Modified Triple-Helix Forming Oligonucleotides Containing a Triglycyl Linker" 5 : 666-668, 1994
5 Arnold, P., "Superparamagnetic iron oxide (SPIO) enhancement in the cirrhotic liver: a comparison of two doses of ferumoxides in patients with advanced disease" 21 : 695-700, 2003
6 Akiyoshi, K., "Stabilization of Insulin upon Supramolecular Complexation with Hydrophobized Polysaccharide Nanoparticle" 8 : 707-708, 1995
7 Lauffer, R. B., "Preparation and water relaxation properties of proteins labeled with paramagnetic metal chelates" 3 : 11-16, 1985
8 Ladd, D. L., "Polymeric Gadolinium Chelate Magnetic Resonance Imaging Contrast Agents: Design, Synthesis and Properties" 10 : 361-370, 1999
9 Thunus, L., "Overview of transition metal and lanthanide complexes as diagnostic tools" 184 : 125-155, 1999
10 Aime, S., "One-step synthesis of a new eight-membered cyclic ligand from glycine, formaldehyde and hypophosphorous acid" 43 : 8387-8389, 2002
11 Albrecht, S., "Iron oxide particles for molecular magnetic resonance imaging cause transient oxidative stress in rat macrophages" 36 : 976-984, 2004
12 Tatsuhirom, Y., "In vivo MR detection of vascular endothelial injury using a new class of MRI contrast agent. Bioorg" 14 : 2787-2790, 2004
13 Tournier, H., "Gadolinium-Containing Mixed Micelle Formulations: A New Class of Blood Pool MRI/MRA Contrast Agents" 9 : S20-S28, 2002
14 Reichert, D. E., "Anderson. Metal complexes as diagnostic tools" 184 : 3-66, 1999
15 Schmiedl, U., "Albumin labeled with Gd-DTPA as an intravascular, blood pool-enhancing agent for MR imaging: biodistribution and imaging studies" 162 : 205-210, 1987
돼지지방, 올리브유 및 대두유를 첨가한 분쇄돈육의 품질 및 기호성
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옥수수 (Zea mays) 뿌리의 알데히드 산화효소와 생장에 미치는 텅스텐산 나트륨의 영향
학술지 이력
연월일 | 이력구분 | 이력상세 | 등재구분 |
---|---|---|---|
2027 | 평가예정 | 재인증평가 신청대상 (재인증) | |
2021-01-01 | 평가 | 등재학술지 유지 (재인증) | |
2018-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2015-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2011-08-03 | 학술지명변경 | 외국어명 : Korean Journal of Life Science -> Journal of Life Science | |
2011-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2009-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2007-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2004-01-01 | 평가 | 등재학술지 선정 (등재후보2차) | |
2003-01-01 | 평가 | 등재후보 1차 PASS (등재후보1차) | |
2001-07-01 | 평가 | 등재후보학술지 선정 (신규평가) |
학술지 인용정보
기준연도 | WOS-KCI 통합IF(2년) | KCIF(2년) | KCIF(3년) |
---|---|---|---|
2016 | 0.37 | 0.37 | 0.42 |
KCIF(4년) | KCIF(5년) | 중심성지수(3년) | 즉시성지수 |
0.43 | 0.43 | 0.774 | 0.09 |