신경병증성 통증의 처리 과정에 있어 중추신경계의 가소성 변화 비교 = Comparisons of the Plastic Changes in the Central Nervous System in the Processing of Neuropathic Pain

다국어 초록 (Multilingual Abstract)

According to International Associating for the Study of Pain (IASP) definition, neuropathic pain is a disorder characterized by dysfunction of the nervous system that, under normal conditions, mediates virulent information to the central nervous system (CNS). This pain can be divided into a disease with provable lesions in the peripheral or central nervous system and states with an incorporeal lesion of any nerves. Both conditions undergo long-term and chronic processes of change, which can eventually develop into chronic pain syndrome, that is, nervous system is inappropriately adapted and difficult to heal. However, the treatment of neuropathic pain itself is incurable from diagnosis to treatment process, and there is still a lack of notable solutions. Recently, several studies have observed the responses of CNS to harmful stimuli using image analysis technologies, such as functional magnetic resonance imaging (fMRI), positron emission tomography (PET), and optical imaging. These techniques have confirmed that the change in synaptic-plasticity was generated in brain regions which perceive and handle pain information. Furthermore, these techniques helped in understanding the interaction of learning mechanisms and chronic pain, including neuropathic pain. The study aims to describe recent findings that revealed the mechanisms of pathological pain and the structural and functional changes in the brain. Reflecting on the definition of chronic pain and inspecting the latest reports will help develop approaches to alleviate pain.

참고문헌 (Reference)

1 김진원, "통증척도 (VAS) 의 타당도 검증과 통증정도에 따른 신체활동량 기준치: 여성요통환자대상" 한국체육측정평가학회 15 (15): 29-39, 2013

2 민양기, "신경병성 통증의 진단과 치료" 대한의사협회 51 (51): 1139-1148, 2008

3 이경규, "만성 통증 환자에서의 정신약물학적 치료" 대한정신약물학회 19 (19): 77-84, 2008

4 조상훈, "만성 신경병성 통증의 약물 치료 : 근거-중심의 약물 치료" 대한안면통증∙구강내과학회 36 (36): 139-146, 2011

5 Lutz, B. M., "mTOR, a new potential target for chronic pain and opioid-induced tolerance and hyperalgesia" 11 : 32-, 2015

6 Williams, A. C. De. C., "Updating the definition of pain" 157 (157): 2420-2423, 2016

7 Craig, A. D., "Topographically organized projection to posterior insular cortex from the posterior portion of the ventral medial nucleus in the long-tailed macaque monkey" 522 (522): 36-63, 2014

8 Craig, A. D., "Thermosensory activation of insular cortex" 3 (3): 184-190, 2000

9 Scholz, J., "The neuropathic pain triad : Neuron, immune cells and glia" 10 : 1361-1368, 2007

10 Fenton, B. W., "The neurobiology of pain perception in normal and persistent pain" 5 (5): 297-317, 2015

11 Jett, M. F., "The effects of mexiletine, desipramine and fluoxetine in rat models involving central sensitization" 69 : 161-169, 1997

12 Brennan, F., "The US Congressional"Decade on Pain Control and Research"2001-2011 : A Review" 29 (29): 212-227, 2015

13 Darrell J. Gaskin, "The Economic Costs of Pain in the United States" Elsevier BV 13 (13): 715-724, 2012

14 Yang, G., "Stably maintained dendritic spines are associated with lifelong memories" 462 (462): 920-924, 2009

15 Dedosterd, I., "Spared nerve injury : An animal model of persistent peripheral neuroapthic pain" 87 : 149-158, 2000

16 Craig, A. D., "Significance of the insula for the evolution of human awareness of feelings from the body" 1225 : 72-82, 2011

17 Dzau, V. J., "Relieving pain in America : Insights from an Institute of Medicine Committee" 312 : 1507-1508, 2014

18 Jonathan Brooks, "REVIEW: From nociception to pain perception: imaging the spinal and supraspinal pathways" Wiley 207 (207): 19-33, 2005

19 Mitchell B. Max, "Quality Improvement Guidelines for the Treatment of Acute Pain and Cancer Pain" American Medical Association (AMA) 274 (274): 1874-1880, 1995

20 Bird, G. C., "Protein kinase A-dependent enhanced NMDA receptor function in pain-related synaptic plasticity in rat amygdala neurons" 564 (564): 907-921, 2005

21 Han, J., "Plasticity-related PKM zeta signaling in the insular cortex is involved in the modulation of neuropathic pain after nerve injury" 2015 : 601767-, 2015

22 Kohno, T., "Peripheral axonal injury results in reduced mu opioid receptor pre- and post- synaptic action in the spinal cord" 117 (117): 77-87, 2005

23 Thacker, M. A., "Pathophysiology of peripheral neuropathic pain : Immune cells and molecules" 105 (105): 838-847, 2007

24 Peyron, R., "Parietal and cingulate process in central pain. a combined postiron emission tomography (PET) and functional magnetic resonance imaging (fMRI) study of an unusual case" 84 (84): 77-87, 2000

25 Um, S. W., "Pain-relieving effects of mTOR inhibitor in the anterior cingulate cortex of neuropathic rats" 56 : 2482-2494, 2019

26 Herr, K., "Pain assessment in the patient unable to self-report : Position statement with clinical practice recommendations" 12 (12): 230-250, 2011

27 Ingvar, M., "Pain and functional imaging. Philosophical Transactions of the Royal Society of London" 354 : 1347-1358, 1999

28 Samineni, V. K., "Neuropathic pain-induced enhancement of spontaneous and pain-evoked neuronal activity in the periaqueductal gray that is attenuated by gabapentin" 158 (158): 1241-1253, 2017

29 Lee, Y., "Neuropathic pain" 23 (23): 171-174, 2002

30 Tsuda, M., "Neuronal and microglial mechanisms for neuropathic pain in the spinal dorsal horn and anterior cingulate cortex" 141 (141): 486-498, 2017

31 최윤정, "Neuroaesthetics: A Concise Review of the Evidence Aimed at Aesthetically Sensible Design" 한국감성과학회 17 (17): 45-54, 2014

32 Khoromi, S., "Morphine, nortriptyline and their combination vs. placebo in patients with chronic lumbar root pain" 130 : 65-75, 2007

33 Kaang, B. K., "Memory and Synaptic Plasticity" 1 (1): 13-24, 2001

34 Mackey, S., "Managing twin crises in chronic pain and prescription opioids" 364 : I917-, 2019

35 Qu, C., "Lesion of the rostral anterior cingulate cortex eliminates the aversiveness of spontaneous neuropathic pain following partial or complete axotomy" 152 (152): 1641-1648, 2011

36 Kwon, M., "Inhibition of Mammalian Target of Rapamycin (mTOR) signaling in the insular cortex alleviates neuropathic pain after peripheral nerve injury" 10 : 79-, 2017

37 Ankesh Kukkar, "Implications and mechanism of action of gabapentin in neuropathic pain" 대한약학회 36 (36): 237-251, 2013

38 Johansen, J. P., "Glutamatergic activation of anterior cingulate cortex produces an aversive teaching signal" 7 (7): 398-403, 2004

39 Peyron, R., "Functional imaging of brain responses to pain. a review and meta-analysis" 30 : 263-288, 2000

40 Casey, K. L., "Forebrain mechanisms of nociception and pain : Analysis through imaging" 96 (96): 7668-7674, 1999

41 Kim, K., "Effects of mTOR inhibitors on neuropathic pain revealed by optical imaging of the insular cortex in rats" 1733 : 146720-, 2020

42 Ghaderi, F., "Effect of pre-cooling injection site on pain perception in pediatric dentistry: “A randomized clinical trial”" 10 (10): 790-794, 2013

43 Tabata, M., "Differential induction of c-Fos and phosphorylated ERK by a noxious stimulus after peripheral nerve injury" 128 (128): 208-218, 2018

44 Narita, M., "Comparative pharmacological profiles of morphine and oxycodone under a neuropathic pain-like state in mice : Evidence for less sensitivity to morphine" 33 (33): 1097-1112, 2008

45 Merskey, H., "Classification of chronic pain: descriptions of chronic pain syndromes and definition of pain terms" IASP Press 1994

46 Sirianni, J., "Chronic pain syndromes, mechanisms, and current treatments" 131 : 565-611, 2015

47 B.V. MacFarlane, "Chronic Neuropathic Pain and Its Control by Drugs" Elsevier BV 75 (75): 1-19, 1997

48 Latremoliere, A., "Central sensitization : A generator of pain hypersensitivity by central neural plasticity" 10 (10): 895-926, 2009

49 Li, K. W., "Calcium channel alpha2delta1 proteins mediate trigeminal neuropathic pain states associated with aberrant excitatory synaptogenesis" 289 (289): 7025-7037, 2014

50 McQuay, H., "Anticonvulsant drugs for management of pain : A systemic review" 311 : 1047-1052, 1995

51 Wager, T. D., "An fMRI-based neurologic signature of physical pain" 368 (368): 1388-1397, 2013

52 Schweinhardt, P., "An fMRI study of cerebral processing of brush-evoked allodynia in neuropathic pain patients" 32 : 256-265, 2006

53 Lee, B. H., "An animal model of neuropathic pain employing injury to the sciatic nerve branches" 11 (11): 657-661, 2000

54 Li, X. Y., "Alleviatiting neuropathic pain hypersensitiviy by inhibiting PKM zeta in the anterior cingulate cortex" 330 (330): 1400-1404, 2010

55 Mutso, A. A., "Abnormalities in hippocampal functioning with persistent pain" 32 (32): 5747-5756, 2012

56 Seltzer, Z., "A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury" 43 : 205-218, 1990