Polymorphisms of interleukin-10 and tumour necrosis factor-&agr; genes are associated with newly diagnosed and recurrent pulmonary tuberculosis

다국어 초록 (Multilingual Abstract)

<P>Background and objectives: </P><P>The genetic determinants for developing TB or having recurrent TB are unknown. The present study investigated the relationship between susceptibility to tuberculosis and human tumour necrosis factor-&agr; (TNF-&agr;) and interleukin-10 genes (IL-10).</P><P>Methods: </P><P>A case–control study was conducted using two groups of cases—newly diagnosed TB (N-TB) and recurrent TB (R-TB)—and a control group.</P><P>Results: </P><P>One hundred and seventeen healthy controls, 80 newly diagnosed TB patients and 65 patients with recurrent TB were enrolled. There was no significant difference in the TNF-&agr;−308 G/A genotype between the TB patient groups and the controls. The IL-10 −1082A alleles were markedly over-represented among the TB patient groups compared with the control subjects, however, there was no significant difference in the IL-10 genotype frequency between the N-TB and R-TB patient groups.</P><P>Conclusion: </P><P>The −1082A allele of the IL-10 gene may be important in determining susceptibility to TB, however, the −308 allele of the TNF-&agr; gene does not affect differential TB susceptibility.</P>