비중격 천공에 의해 늦게 진단된 결절외 비성 Natural Killer/T 세포 림프종 1예 = Delayed Diagnosis Due to Septal Perforation in Patient with Extranodal Natural Killer/T-Cell Lymphoma, Nasal Type

다국어 초록 (Multilingual Abstract)

Extranodal natural killer (NK)/T-cell lymphoma, nasal type is a rare non-Hodgkin lymphomaoriginating in the nasal cavity or in the paranasal sinuses, and is etiologically closely related withthe Epstein Barr Virus infection. It is more commonly found in East Asia, South America, andMexico than in Europe or North America. Extranodal NK/T-cell lymphoma, nasal type typicallyshows a crust on the nasal mucosal surface, necrosis, and inflammation. Pathologically, itpresents as significant vascular damage and destruction, with apparent tissue necrosis and cytotoxicity.
These neoplasms are very aggressive and can show septal perforation, diffuse ulcer lesionon the nasal mucosa, fistula or epistaxis. We experienced a case of the extranodal NK/Tcelllymphoma, nasal type at the nasal septum, which was delayed in diagnosis due to septalperforation, which occurred after septoplasty in a 47-year-old female. Thus, we report this casewith a review of literatures.

참고문헌 (Reference)

1 Kim SJ, "Treatment of localized extranodal NK/T cell lymphoma, nasal type: A systematic review" 11 (11): 140-, 2018

2 Slater DN, "The new World Health Organization-European Organization for Research and Treatment of Cancer classification for cutaneous lymphomas: A practical marriage of two giants" 153 (153): 874-880, 2005

3 Kwong YL, "Natural killer-cell malignancies: Diagnosis and treatment" 19 (19): 2186-2194, 2005

4 Mahir K, "NK/T-cell lymphoma presenting as a post-operative nasal septal perforation: A diagnostic challenge" 4 (4): 037-, 2018

5 Tlholoe MM, "Extranodal natural killer/T-cell lymphoma, nasal type: ‘Midline lethal granuloma.’ A case report" 9 : 4-, 2013

6 Kim J, "Extranodal nasal-type NK/T-cell lymphoma: Computed tomography findings of head and neck involvement" 51 (51): 164-169, 2010

7 Al-Hakeem DA, "Extranodal NK/T-cell lymphoma, nasal type" 43 (43): 4-14, 2007

8 Guan P, "Extranodal NK/T-cell lymphoma in adolescents: Imaging findings of a consecutive 7-year case series" 47 (47): 1210-1220, 2019

9 Haverkos BM, "Extranodal NK/T cell lymphoma, nasal type (ENKTL-NT): An update on epidemiology, clinical presentation, and natural history in North American and European cases" 11 (11): 514-527, 2016

10 Weiss LM, "EBER in situ hybridization for Epstein-Barr virus" 999 : 223-230, 2013

11 Fairbanks DN, "Closure of nasal septal perforations" 106 (106): 509-513, 1980