Synthesis of Silicon Traceless Linker for Solid-Phase Reaction

다국어 초록 (Multilingual Abstract)

The silicon linker is the foremost traceless linker used in solid-phase reactions. Hydrogen fluoride
(HF) or trifluoroacetic aicd (TFA) can remove the silicon linker with the silicon atom being
replaced by a hydrogen atom. In this experiment, the linkers 1c and 2d, which are the most
useful in solid-phase reactions, were synthesized. Linker 1c is composed of seven linearly
linked carbons and linker 2d includes an oxygen atom in the linear carbon chain to increase
the solvation capacity. The carboxylic acid component of linker 1c and 2d forms an amide or
ester bond with resin. The synthesized linkers 1c and 2d could be utilized in constructing a
chemical compound library that includes indole, benzodiazepine and phenothiazine (aromatic
ring compounds).

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