Iodine Impregnated Poly(N-Vinylpyrrolidone) Grafted Antibacterial Cotton Gauze for Wound Dressing Applications

다국어 초록 (Multilingual Abstract)

The purpose of the present work was to modify the absorbent cotton gauze to improve its functionality asantimicrobial wound dressing. The cotton gauze was modified by grafting of N-vinyl-pyrrolidone using microwave-assistedreactions. The effect of volume of N-vinyl-pyrrolidone and amount of ammonium persulfate on percentage grafting wasoptimized by 2-factor, 3-level central composite experimental design. The optimized batch of gauze-g-NVP wasimpregnated with iodine. The iodine-loaded gauze-g-NVP was characteristically examined by Fourier-transformed infraredspectroscopy and Field emission-scanning electron microscopy studies. The results of energy dispersive X-ray analysisconfirmed the uniform dispersion of iodine on the surface of iodine impregnated poly(NVP)-g-cotton gauze. Further, theiodine-loaded gauze-g-NVP showed blood absorbency and in vitro blood clotting ability comparable to the absorbent cottongauze. However, a significantly higher antimicrobial activity of iodine-loaded gauze-g-NVP against the Staphylococcusaureus and Escherichia coli was observed as compared to the iodine solution of equivalent concentration which can beattributed to the higher retention of iodine at the site of action. In the nutshell, results show that iodine-loaded grafted cottongauze have the desirable and effective antibacterial wound dressing property with excellent blood absorbency and clottingabilities.

참고문헌 (Reference)

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