국소진행성 직장암에서 선행항암화학방사선요법 후 종양퇴행에 영향을 미치는 요인

다국어 초록 (Multilingual Abstract)

Purpose: Neoadjuvant chemoradiotherapy is the standard of care for locally advanced rectal cancer. The aim of this retrospective study was to identify factors affecting tumor regression after neoadjuvant chemoradiotherapy of locally advanced rectal cancer.
Methods: From January 2011 to December 2016, retrospective analysis was performed on 93 patients with locally advanced rectal cancer who were received neoadjuvant chemoradiotherapy followed by radical surgery. The total dose of radiation was 54Gy, 2Gy was irradiated once a day for 5 days per week. Of 93 patients, 72 patients received concurrent infusional 5-fluorouracil and leucovorin, while 21 patients received oral capecitabine during radiotherapy. Tumor regression grade(TRG) system was applied by simplifying Dworak TRG.
Results: Of the 93 patients, 54 (58.1%) cases were excellent tumor regression response(TRR)(Dworak TRG 3-4). Univariate analysis demonstrated that age, over 65 years old, was significant predictive factor for excellent TRR (P=0.003). The results from the multivariate analysis also indicated that age (Odd ratio, 0.21; P=0.002) was significant predictive factor.
Conclusion: Over 65 years old age patients was predictor for excellent TRR. That would be helpful for treatment guidelines for old age patients. However, there are many restriction in retrospective study, so we recommend the randomized prospective study.

Key Words: Locally advanced rectal cancer, Neoadjuvant chemoradiotherapy, Tumor regression

목차 (Table of Contents)

• Index
• I.Abstract····························································································1
• II.Introduction····················································································3
• III.Method···························································································5
• 1)Material
• 2)Examination before treatment
• 3)Chemoradiotherapy
• 4)Tumor regression
• 5)Statistical analysis
• IV.Result····························································································8
• V.Discussion··················································································10
• VI.Conclusion·················································································14
• VII.Reference··················································································15