하악골신장술시 불화나트륨 투여의 초기효과에 대한 실험적 연구 = (An)experimental study on the early effects of sodium fluoride after distraction osteogenesis in dogs

다국어 초록 (Multilingual Abstract)

Distraction osteogenesis is a surgical-orthopedic technique to lengthen a bone by separating or distracting a fracture callus. The purpose of this study was to observe the effects of sodium fluoride on the bony repair and regeneration processes after distraction osteogenesis in dogs. Four adult dogs were employed for this experiment. Four dogs were divided into experimental and control groups. The distraction was undertaken at the rate of 0.75mm a day for 15 consecutive days to yield 12.25mm lengthening of mandibular corpus. One mg NaF/kg of body weight/day were given orally to the experimental group. The animals were euthanized at two and four weeks after the completion of distraction, and radiologic, histologic, and histomorphometric examinations were achieved.
The results were as follows ;
1. At two weeks after completion of distraction, the active osteoblasts lining the osteoid at the surface of trabecular bony spicules and active new bone formation were observed in the both groups. However, the cellular activity and new bone formation were more prominent in the experimental group.
2. At four weeks after completion of distraction, the continuous osteoid and new bone formation and active osteoblasts were observed in the experimental group. But these phenomena were decreased in the control group.
These results imply that sodium fluoride has the stimulation effects on the osteoid production of the osteoblasts during the healing process after distraction osteogenesis more continuously.

목차 (Table of Contents)

• I. 서론
• II. 연구재료 및 방법
• III. 연구결과
• IV. 총괄 및 고안
• V. 결론
• 참고문헌
• 영문초록
• 사진부도 및 설명