PGC-1α유전자 다형성과 신체활동 수준에 따른 대학생의 신체구성, 혈압, 심폐체력의 비교 = Comparisons of body composition, blood pressure, and cardiorespiratory fitness according to PGC-1a gene polymorphisms and physical activity Levels in college students

국문 초록 (Abstract)

본 연구의 목적은 국내 20대 건강한 남녀 대학생을 대상으로 PGC-1α유전자 다형(유전적) 및 PGC-1α 유전자 다형과 신체활동 수준(상중하)(유전적＋환경적)에 따른 신체구성, 혈압 및 심폐체력의차이를 검증하는데 있다. 연구의 대상자는 20대의 건강한 남녀 대학생 총 1286명을 대상으로 신체구성(신장, 체중, BMI, BF%, muscle, waist, WHR), 혈압 및 심폐체력을 측정하였고, Real-Time PCR을 이용하여 PGC-1a Gly482Ser을 분석하였다. 총 1286명을 대상으로 관찰된 PGC-1α 유전자다형의 빈도를 이용한 Hardy-Weinberg 평형성을 검정한 결과, 관찰된 PGC-1α 유전자 형질의 빈도는 기대(예측)빈도와 유의한 차이를 나타내지 않았다. 한국 20대 건강한 남녀 대학생을 대상으로 PGC-1α Gly482Ser 유전자 다형에 따른 신체구성, 혈압 및 심폐체력은 차이가 없었다. 또한 PGC-1α Gly482Ser 유전자 다형과 신체활동 수준(상중하)에 따른 신체구성과 혈압은 차이가 없었다. 하지만 중간 수준의 신체활동을 하는 집단에서 PGC-1α Gly482Ser 유전자 다형에 따른 심폐체력은 차이가 있었다. 결론적으로, 한국의 건강한 대학생의 PGC-1α Gly482Ser 유전자 다형은 신체구성, 혈압 그리고 심폐체력의 차이를 결정짓는 유전자가 아닌 것으로 판단되며, PGC-1α Gly482Ser 유전자 다형과 신체활동 수준은 신체 구성과 혈압의 차이를 결정짓는 유전적 환경적 요인이 아닌 것으로 판단된다.

다국어 초록 (Multilingual Abstract)

The purpose of this study was to investigate whether or not the PGC-1a gene polymorphisms and physical activity levels was associated with body composition, blood pressure and cardiorespiratory fitness(CRF) in korean college students. The PGC-1a gene were genotype in 1286 Korean college students by using the Real-Time Quantitative PCR with TaqMan detection chemistry, CRF was measured as the maximum volume of minute oxygen consumption during a graded treadmill testing, Body composition(height, weight, body mass index, percent body fat, waist, WHR) and blood pressure were measured using our standardized protocols. Chi-square analysis was used to test the Hardy-Weinberg equilibrium based on the genotype frequencies of the PGC-1a gene polymorphism in the study population, and its relative frequency were in the Hardy-Weinberg equilibrium. Therefore, it was confirmed that a sample size(n=1286) of the current study represented the total population appropriately in terms of the PGC-1a genotype distribution. On the other hand, body composition, blood pressure a nd C RF was not s ignificantly d ifferent across the P G C-1a genotypes. Also, body composition and blood pressure was not significantly different across the PGC-1a genotypes and physical activity levels. but CRF was significantly different across the PGC-1a genotypes and middle level of physical activity. In conclusion, the current findings suggest that the PGC-1a genotype is not associated with the body composition, blood pressure and CRF in the korean college s tudents. Also, PGC-1a genotype and physical activity levels is not associated with the body composition, blood pressure in the korean college students.

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