Polymeric Nanofiber Coated Esophageal Stent for Sustained Delivery of an Anticancer Drug

다국어 초록 (Multilingual Abstract)

In this study, we developed an esophageal stent capable of sustained delivery of an anticancer drug, fluorouracil (5-FU). The stents were coated with drug-loaded poly(lactic-co-glycolic acid) (PLGA) nanofibers (DPN)via the electrospinning method, which exhibited a sustained drug release for up to 6 days. To prolong drug release,we also added the nanofiber layers composed of PLGA alone (PN), surrounding the DPN layer, as a more resistive diffusion barrier, where a period of drug release could be extended to 21 days with the DPN layer topped with another 192 μm thick PN layer. Therefore, we envisioned longer period of drug release with the thicker PN layers,obtained simply with a longer collection time of PLGA nanofibers via electrospinning. Overall, we concluded that the drug-delivery esophageal stent prepared in this study is promising in the long-term treatment of dysphagia caused by esophageal cancer.

참고문헌 (Reference)

1 H. Gao, 118 : 325-, 2007

2 Z. Xie, 115 : 1-, 2010

3 J. Muller, 77 : 845-, 1990

4 P. Enzinger, 349 : 2241-, 2003

5 M. Sundelof, 42 : 11-, 2007

6 D. Xinopoulos, 22 : 354-, 2009

7 J. Ellul, 82 : 1678-, 1995

8 R. C. Eberhart, 14 : 299-, 2003

9 R. Tung, 144 : 913-, 2006

10 G. Nakazawa, 6 : 33-, 2009

11 S. Jeon, 41 : 449-, 2009

12 Q. Guo, 118 : 318-, 2007

13 S. R. Guo, 99 : 3009-, 2010

14 K. Kuraishi, 88 : 230-, 2009

15 J. E. Puskas, 1 : 451-, 2009

16 D. Longley, 3 : 330-, 2003

17 A. Jemal, 59 : 225-, 2009

18 K. Zhu, 20 : 731-, 2003

19 R. Jayakumar, 28 : 142-, 2010

20 J. Fang, 53 : 2265-, 2008

21 E. M. L. Verschuur, 103 : 304-, 2008

22 Z. M. Huang, 63 : 2223-, 2003

23 R. Vasita, 95 : 1605-, 2010

24 C. Shim, 33 : 843-, 2001

25 C. Berkland, 25 : 5649-, 2004

26 K. Dillen, 275 : 171-, 2004

27 X. Zong, 43 : 4403-, 2002

28 A. R. Gennaro, "Remington’s Pharmaceutical Sciences" Mack Publishing Company 1975

29 Jin Soo Lee, "Preparation of 5-Fluorouracil-Loaded Poly(L-lactide-co-glycolide) Wafer and Evaluation of In Vitro Release Behavior" 한국고분자학회 11 (11): 183-188, 2003

30 N. Washington, "Physiological pharmaceutics: barriers to drug absorption" CRC Press 2001

31 C. E. Wilkes, "PVC handbook" Hanser Gardner Publications 2005

32 X. S. Wu, "Encyclopedic handbook of biomaterials and bioengineering" Marcel Dekker 1015-, 1995