<P><B>Abstract</B></P> <P><B>Background and objectives</B></P> <P>Axillary lymph node (ALN) status is a key indicator in assessing and determining the treatment strategy for patients with newly di...
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https://www.riss.kr/link?id=A107447335
2018
-
SCI,SCIE,SCOPUS
학술저널
129-137(9쪽)
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
<P><B>Abstract</B></P> <P><B>Background and objectives</B></P> <P>Axillary lymph node (ALN) status is a key indicator in assessing and determining the treatment strategy for patients with newly di...
<P><B>Abstract</B></P> <P><B>Background and objectives</B></P> <P>Axillary lymph node (ALN) status is a key indicator in assessing and determining the treatment strategy for patients with newly diagnosed breast cancer. Previous studies suggest that sonographic features of a primary tumor have the potential to predict ALN status in the preoperative staging of breast cancer. In this study, a computer-aided prediction (CAP) model as well as the tumor features for ALN metastasis in breast cancers were developed using breast ultrasound (US) images.</P> <P><B>Methods</B></P> <P>A total of 249 malignant tumors were acquired from 247 female patients (ages 20–84 years; mean 55 ± 11 years) to test the differences between the non-metastatic (130) and metastatic (119) groups based on various features. After applying semi-automatic tumor segmentation, 69 quantitative features were extracted. The features included morphology and texture of tumors inside a ROI of breast US image. By the backward feature selection and linear logistic regression, the prediction model was constructed and established to estimate the likelihood of ALN metastasis for each sample collected.</P> <P><B>Results</B></P> <P>In the experiments, the texture features showed higher performance for predicting ALN metastasis compared to morphology (<I>Az</I>, 0.730 vs 0.667). The difference, however, was not statistically significant (<I>p</I>-values > 0.05). Combining the textural and morphological features, the accuracy, sensitivity, specificity, and <I>Az</I> value achieved 75.1% (187/249), 79.0% (94/119), 71.5% (93/130), and 0.757, respectively.</P> <P><B>Conclusions</B></P> <P>The proposed CAP model, which combines textural and morphological features of primary tumor, may be a useful method to determine the ALN status in patients with breast cancer.</P> <P><B>Highlights </B></P> <P> <UL> <LI> A computer-aided prediction (CAP) system contained automatic tumor segmentation and feature quantification on breast ultrasound was developed to evaluate the axillary lymph node (ALN) status in the preoperative staging with breast cancer. </LI> <LI> The proposed CAP model based on morphological and textural features of primary tumor would provide a promising diagnostic suggestion for recognizing the breast cancers as a case of ALN metastasis. </LI> <LI> In view of there has been a decrease in the patients presented with palpable ALN at diagnosis of breast cancer, a non-invasive examination like our CAP model may help physicians in the choice of the optimal axillary approach. </LI> </UL> </P>
Skin lesion segmentation in dermoscopy images via deep full resolution convolutional networks