쥐의 급식회수와 체지방과잉합성 = Frequency of Meals and Hyperlipogenesis of Rat

다국어 초록 (Multilingual Abstract)

This experiment was performed to investigate the effect of the frequency of meals on the methbolism and the body composition of rats when equal amount of purified diet was ingested. Thirty approximately days old rats weighting 290g and thirty-two about 40 days old rats weighing 180g were employed for the period of 34 days.
Rats fed (10 to 15 meals per day) and two-meal per day were pair-fed and equal amount of die was fed to each rat in pair. The experienced results obtained are summarized as follows:
1. Frequency of meal did not exert any effect on the body weight gain. However, rats fed two-meal per day gained significantly (p$lt;0.005) more fat and energy than ad libitum group. The rate of gain of proteia in ad libitum group was higher than that of two-meal group. No difference was observed for the mineral deposition of rat body.
2. From the preparation of rat liver it was found that the activity of glucose-6-phosphate dehydrogenase was much higher for the rats fed two-meals per day than those fed ad libitum. Therefore, it is suggested that the metablic pathway of carbohydrate for two-meal group has been shifted from glycolysis to Hexose Monophosphate Shunt and produced more NADPH which would be the essential cofactor of fatty acids synthesis.
3. The rate of excretion of urinary nitrogen for two-meal group was significantly (p$lt;0.005) higher than that of ad libitum group. It is apparent that considerable amount of over-loaded amino acids by feeding two-big-meal daily could not be used for the protein biosynthesis all at once and excreted following deamination through urine. The residual carbon chain could be served as a precursor of fatty acids synthesis.
4. The heat production rate of rats fed two-meal group was significantly (p$lt;0.005) lower than that of ad libitum group, It seems possible that the activity of thyroid gland (and consequently BMR) can be depressed by the frequency of meal.