The experimental evidences of steamed and freeze-dried mature silkworm powder as the calorie restriction mimetics

다국어 초록 (Multilingual Abstract)

Steamed and freeze-dried mature silkworm powder (SMSP) is a natural food containing a large amount of various functional materials and has various health promoting effects. SMSP is known to increase the life expectancy and healthspan, simultaneously. The accomplishment of extension of healthspan should be possible to achieve by activating various signaling pathways delaying aging in various tissues, not by regulating only a few signaling pathways. Consistent with this notion, SMSP increased the resistant to Parkinson disease by enhancing olfaction and mitochondrial activity in neurons of animal models. In addition, SMSP could enhance the gastrointestinal functions. The animals consumed SMSP showed enhanced alcohol metabolisms, reduced cholesterols in bloods, increased resistance to carcinogens causing liver cancers, and protective effects in alcohol induced stomach ulcers. Furthermore, SMSP was also effective in appearance. The SMSP consumed animals showed reduced skin pigmentations and more hair growth compared with control animals. Taken together, the functional enhancement effects of SMSPs in various tissues and organs, which have been discovered to date, are combined to extend healthspan. Therefore, SMSP can be regarded as calorie restriction mimetics. Further studies in the health promoting effects of SMSP will contribute to identifying new applicable diseases, resulted in increased sales of SMSP and incomes of sericulture farmers.

참고문헌 (Reference)

1 "e Country Index"

2 Di Meglio P, "The multitasking organ : recent insights into skin immune function" 35 : 857-869, 2011

3 Simopoulos AP, "The importance of the ratio of omega-6/omega-3 essential fatty acids" 56 : 365-379, 2002

4 KangSunRyu, "The Tonic Effect of the Extract from Male Silkworm (Bombyx mori L.) Pupae on Rats" 한국잠사학회 5 (5): 123-126, 2002

5 "The Korean Geriatrics Society"

6 Knickman JR, "The 2030 problem : caring for aging baby boomers" 37 : 849-884, 2002

7 "Statics Korea"

8 Hong KS, "Silkworm(Bombyx mori)powder supplementation alleviates alcoholic fatty liver disease in rats" 43 : 29-36, 2018

9 Tomotake H, "Silkworm pupae(Bombyx mori)are new sources of high quality protein and lipid" 56 : 446-448, 2010

10 Burnier M, "Should we eat more potassium to better control blood pressure in hypertension?" 34 : 184-193, 2018

11 Tanner CM, "Rotenone, Paraquat, and Parkinson’s Disease" 119 : 866-872, 2011

12 Catalgol B, "Resveratrol : French paradox revisited" 3 : 141-, 2012

13 최보혜, "Quantification and comparison of functional phytochemicals in steamed and freeze-dried mature silkworm powders and freeze-dried mulberry leaves" 한국잠사학회 35 (35): 89-96, 2017

14 Jae-Min Cho, "Protective Effect of Boiled and Freeze-dried Mature Silkworm Larval Powder Against Diethylnitrosamine-induced Hepatotoxicity in Mice" 대한암예방학회 21 (21): 173-181, 2016

15 최보혜, "Phytochemicals and silk proteins in mature silkworm powders responsible for extended life expectancy and enhanced resistances to Parkinson's disease" 한국응용곤충학회 20 (20): 1425-1433, 2017

16 Mishra N, "Nutritive value of non-mulberry and mulberry silkworm pupae and consumption pattern in Assam, India" 23 : 1303-1311, 2003

17 지상덕, "Nutrition composition differences among steamed and freeze-dried mature silkworm larval powders made from 3 Bombyx mori varieties weaving different colored cocoons" 한국잠사학회 33 (33): 6-14, 2016

18 Sang Deok Ji, "Nutrient compositions of Bombyx mori mature silkworm larval powders suggest their possible health improvement effects in humans" 한국응용곤충학회 19 (19): 1027-1033, 2016

19 Kim DK, "Neuroprotection and enhancement of learning and memory by BF-7" 5 : 317-324, 2005

20 Jin H, "Mitochondria-targeted antioxidants for treatment of Parkinson's disease : Preclinical and clinical outcomes" 1842 : 1282-1294, 2014

21 Phuong Nguyen, "Increased healthspan and resistance to Parkinson's disease in Drosophila by boiled and freeze-dried mature silk worm larval powder" 한국응용곤충학회 19 (19): 551-561, 2016

22 "Health Insurance Review & Assessment Service(2019)"

23 Yun SM, "Gastroprotective effect of mature silkworm, Bombyx mori against ethanol-induced gastric mucosal injuries in rats" 39 : 279-286, 2017

24 Kontis V, "Future life expectancy in 35 industrialised countries : projections with a Bayesian model ensemble" 389 : 1323-1335, 2017

25 Hong-Geun Oh, "Effects of male silkworm pupa powder on the erectile dysfunction by chronic ethanol consumption in rats" 한국실험동물학회 28 (28): 83-90, 2012

26 KangSunRyu, "Effects and Mechanisms of Silkworm Powder as a Blood Glucose-Lowering Agent" 한국잠사학회 4 (4): 93-100, 2002

27 Ferretta A, "Effect of resveratrol on mitochondrial function : Implications in parkin-associated familiar Parkinson's disease" 1842 : 902-915, 2014

28 Kang YK, "Effect of a Fibroin enzymatic hydrolysate on memory improvement : a placebocontrolled, double-blind study" 10 : 233-, 2018

29 Ji SD, "Development of processing technology for edible mature silkworm" 53 : 38-43, 2015

30 Sang-Deok Ji, "Contents of nutrients in ultra-fine powders of steamed and lyophilized mature silkworms generated by four silkworm varieties" 한국응용곤충학회 22 (22): 969-974, 2019

31 지상덕, "Comparison of nutrient compositions and pharmacological effects of steamed and freeze-dried mature silkworm powders generated by four silkworm varieties" 한국응용곤충학회 20 (20): 1410-1418, 2017

32 이다영, "Comparative effect of silkworm powder from 3 Bombyx mori varieties on ethanol-induced gastric injury in rat model" 한국잠사학회 35 (35): 14-21, 2017

33 Coulom H, "Chronic Exposure to Rotenone Models Sporadic Parkinson's Disease in Drosophila melanogaster" 24 : 10993-10998, 2004

34 Ingram DK, "Calorie restriction mimetics : Can you have your cake and eat it, too?" 20 : 46-62, 2015

35 Fernández-Ruiz I, "Calorie restriction for healthy ageing" 14 : 190-, 2017

36 Testa G, "Calorie restriction and dietary restriction mimetics : a strategy for improving healthy aging and longevity" 20 : 2950-2977, 2014

37 김현진, "Anti-melanogenic activity of steamed and freeze-dried mature silkworm powder" 한국응용곤충학회 20 (20): 1001-1006, 2017

38 Ryu KS, "An activity of lowering blood-glucose levels accoring to preparative conditions of silkworm powder" 39 : 79-85, 1997

39 Niccoli T, "Ageing as a risk factor for disease" 22 : R741-R752, 2012