생리적 자극에 따른 신생 새끼 돼지 뇌간 혈류량의 변화 = Brain Stem Blood Flow During Hypercapnia, Hypocapnia, Hypoxia, and Hemorrhagic Hypotension in Newborn Piglet

다국어 초록 (Multilingual Abstract)

Changes of brain stem blood flow(BBF) during physiologic stimulation, such as hypoxia, hypo-and hypercapnia, and hemorrhagic hypotension, were studied by hydrogen clearance technique closed clival window in the brain stem of newborn piglet. Induction of moderate hypercapnia(PaCO₂=65.4±2.11mmHg) caused prominent increases in BBF(354±39% ; p<0.0001). Conversely, in response to moderate hypocapnia(PaCO₂=23.9±0.64mmHg), a significant decreased in BBF(-30.38±3.22% ; p<0.0001) was observed. During severe hypoxia(PaO₂=33.7±1.4mmHg) moderate increases in BBF(161±51.4% ; p=0.005) occurred. Interestingly, in response to systemic hypotension(Mean Arterial Blood Pressure=34±0.7mmHg), a nonsignificant reduction of BBF was recorded (-14±10% ; p=0.240).
These findings suggest that CO₂ reactivity of newborn piglet posterior circulation is high ; however, hypoxic reactivity is relatively moderate, and BBF is autoregulated during systemic hypotension.