The impact of ultrasound on Janus capsules at gel-liquid interface

다국어 초록 (Multilingual Abstract)

Ultrasound-responsive Janus capsules gain increasing recognition in the scientific world due to the wide spectrum of their potential applications. Spherical structures with the heterogeneous shells composed of two kinds of fused polymeric microparticles can be particularly useful when the cargo should be released in a strictly controlled manner. Distinct physical properties of individual hemispheres have a significant impact on the course of the payload release process. In this paper we deal with the problem of the influence of high-frequency and low intensity ultrasound on the behaviour of Janus capsules placed at the gel-liquid interface. Such a boundary between two phases can simulate the natural barriers occurring for example in biological systems. We show that 1 MHz acoustic waves are able to liberate the content from Janus capsule and push the freed liquid cargo through the interface so that it penetrates into the gel medium. We demonstrate that the size of the Janus capsule and, above all, its orientation at the interface in relation to the direction of acoustic wave propagation, are the key factors determining the progress of payload release and its transfer to the gel medium. Shell region that is mechanically weaker tends to break faster, which defines the initial path of payload release.
Presented results contribute to a better understanding of physical phenomena occurring during the interaction of ultrasound with particle capsules. They can also become a source of inspiration not only for further experimental research, but also for theoretical analysis.

참고문헌 (Reference)

1 T. Kubiak, "Ultrasound-triggered directional release from turmeric capsules" 57 : 19-27, 2021

2 H. Jakjoud, "Ultrasound harmonic scattered by fluid spheres, 2009" 267-273, 2009

3 H. A. A. Sidek, "Ultrasonic studies of palm oil and other vegetable oils" 8 : 37-44, 1996

4 C. Berrospe-Rodriguez, "Toward jet injection by Continuous-Wave laser cavitation" 22 : 1-, 2017

5 J. Cook, "Tissue-mimicking phantoms for photoacoustic and ultrasonic imaging" 2 : 3193-3206, 2011

6 B. T. Hayes, "Three-MHz ultrasound heats deeper into the tissues than originally theorized" 39 : 230-234, 2004

7 L. Capurso, "Thirty years of Lactobacillus rhamnosus GG: a review" 53 : 2019

8 A. Jozefczak, "The effect of magnetic nanoparticles on the acoustic properties of tissue-mimicking agar-gel phantoms" 431 : 172-175, 2017

9 S. Liang, "The application of frequency-domain photoacoustics to temperature-dependent measurements of the Grüneisen parameter in lipids" 11 : 56-64, 2018

10 W.R. Hedrick, "Technology for Diagnostic Sonography" 2012

11 E. A. Melo-Espinosa, "Surface tension prediction of vegetable oils using artificial neural networks and multiple linear regression" 57 : 886-895, 2014

12 R. W. Timme, "Speed of sound in Castor oil" 52 : 989-992, 1972

13 M. Vercammen, "Sound reflections from concave spherical surfaces. Part II:Geometrical acoustics and engineering approach" 96 : 92-101, 2010

14 M. Vercammen, "Sound concentration caused by curved surfaces" 133 : 3348-, 2013

15 T. Jeyaseelan, "Predicting surface tension for vegetable oil and biodiesel fuels" 6 : 2016

16 Z. Rozynek, "Patchy colloidosomes – an emerging class of structures" 225 : 741-756, 2016

17 J. S. Sander, "Monodisperse functional colloidosomes with tailored nanoparticle shells" 27 : 3301-3307, 2011

18 S. Meng, "Modeling micro-particles impacts into ballistic gelatine using smoothed particles hydrodynamics method" 39 : 100852-, 2020

19 D. Huang, "Microcapsule-embedded hydrogel patches for ultrasound responsive and enhanced transdermal delivery of diclofenac sodium" 7 : 2330-2337, 2019

20 A. Mikkelsen, "Mechanical properties of particle films on curved interfaces probed through electric field-induced wrinkling of particle shells" 11 : 29396-29407, 2019

21 D. -G. Han, "Measurements of normal incidence reflection loss as a function of temperature at the water-Castor oil interface" 19 : 3289-, 2019

22 V. F. Korolovych, "Impact of high-frequency ultrasound on nanocomposite microcapsules: in silico and in situ visualization" 18 : 2389-2397, 2015

23 D. Veysset, "High-velocity micro-particle impact on gelatin and synthetic hydrogel" 86 : 71-76, 2018

24 C. J. Steenbjerg Ibsen, "Hierarchical tubular structures Grown from the gel/liquid interface" 20 : 16112-16120, 2014

25 K. B. Djagny, "Gelatin: a valuable protein for food and pharmaceutical industries: Review" 41 : 481-492, 2001

26 J.D.N. Cheeke, "Fundamentals and Applications of Ultrasonic Waves" 2002

27 F. Jafari, "Exact evaluation of an ultrasonic scattering formula for a rigid immovable sphere" 7 : 293-296, 1981

28 J. Yeste, "Engineering and monitoring cellular barrier models" 12 : 18-, 2018

29 X. Liu, "Electromagnetic field-programmed magnetic vortex nanodelivery system for efficacious cancer therapy, n/a" 2100950-, 2021

30 Z. Rozynek, "Electrohydrodynamic controlled assembly and fracturing of thin colloidal particle films confined at drop interfaces" 223 : 1859-1867, 2014

31 A. Chakrabarti, "Elastocapillary interaction of particles on the surfaces of ultrasoft gels: a novel route to study self-assembly and soft lubrication" 30 : 4684-4693, 2014

32 T. Grant, "Effect of injection pressure and fluid volume and density on the jet dispersion pattern of needle-free injection devices" 138 : 2015

33 T. Kubiak, "Direction-specific release from capsules with homogeneous or Janus shells using an ultrasound approach" 12 : 15810-15822, 2020

34 B. Issenmann, "Deformation of acoustically transparent fluid interfaces by the acoustic radiation pressure" 83 : 34002-, 2008

35 T. Benameur, "Curcumin as prospective anti-aging natural compound: focus on brain" 26 : 2021

36 A. B. Subramaniam, "Controlled assembly of jammed colloidal shells on fluid droplets" 4 : 553-556, 2005

37 A. Farrer, "Characterization and evaluation of tissue-mimicking gelatin phantoms for use with MRgFUS" 3 : 9-, 2015

38 G. Loget, "Bulk synthesis of Janus objects and asymmetric patchy particles" 22 : 15457-15474, 2012

39 B. Laccetti, "Ballistic delivery of compounds to inner layers of the cornea is limited by tough mechanical properties of stromal tissue" 115 : 104246-, 2021

40 Z. Rozynek, "Assembly and rearrangement of particles confined at a surface of a droplet, and intruder motion in electroshaken particle films" 9 : 2016

41 D. Praditya, "Anti-infective properties of the Golden spice curcumin" 10 : 912-, 2019

42 P. Dommersnes, "Active structuring of colloidal armour on liquid drops" 4 : 2013

43 J. Wu, "Acoustic streaming and its applications" 3 : 2018

44 G. Menikou, "Acoustic and thermal characterization of agar based phantoms used for evaluating focused ultrasound exposures" 5 : 14-, 2017

45 T. -Y. Liu, "A novel drug vehicle capable of ultrasound-triggered release with MRI functions" 7 : 3927-3934, 2011

46 X. Shao, "A method for determining surface tension, viscosity, and elasticity of gels via ultrasonic levitation of gel drops" 147 : 2488-2498, 2020