Effect of Renal Insufficiency on Stone Recurrence in Patients with Urolithiasis

다국어 초록 (Multilingual Abstract)

The study was designed to assess the relationship between glomerular filtration rate (GFR)and urinary stone-forming constituents, and to assess the effect of renal insufficiency onstone recurrence risk in first stone formers (SF). Baseline serum creatinine levels wereobtained, and renal insufficiency was defined as creatinine clearance ≤ 60 mL/min(Cockroft-Gault). This retrospective case-control study consists of 342 first SF; 171 SF withnormal renal function were selected with 1:1 propensity scores matched to 171 SF withrenal insufficiency. Urinary metabolic evaluation was compared to renal function. GFR waspositively correlated with urinary calcium, uric acid, and citrate excretion. Subjects withrenal insufficiency had significantly lower urinary calcium, uric acid, and citrate excretionthan those with normal renal function, but not urine volume. With regard to urinarymetabolic abnormalities, similar results were obtained. SF with renal insufficiency hadlower calcium oxalate supersaturation indexes and stone recurrence rates than SF withnormal renal function. Kaplan-Meier curves showed similar results. In conclusion, GFRcorrelates positively with urinary excretion of stone-forming constituents in SF. This findingimplies that renal insufficiency is not a risk factor for stone recurrence.

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