Effect of Sophora japonica Extract on Lipid Content in High Fat Diet Fed Rats

다국어 초록 (Multilingual Abstract)

The effect of hot water extract of Sophora japonica Linne (Koehwa) flower on lipid content were studied in terms of hematological variables in rats fed with high fat diet. Experimental rats were divided into basal diet only (BDG), high fat diet control (FDC), high fat diet and 6% Sophora japonica extract powder (FD6S), and high fat diet and 12% Sophora japonica extract powder (FD12S) groups. The levels of hematological variables were not significantly different among the four groups, whereas transferrin concentration and glutamic oxaloacetate transaminase (GOT) activity in serum metabolic variables were significantly different. Transferrin concentration was higher in the FD6S and FD12S groups than in BDG and FDC groups. FD6S and FD12S groups
showed significantly lower level of GOT activity. Total cholesterol levels of FD6S and FD12S groups were 220.38 and 205.02 mg/dL in the serum, respectively. Total cholesterol levels of FD6S and FD12S groups were lower than that of FDC group (341.38 mg/dL) and the same level as that of FDG group (216.18 mg/dL). HDL- and LDL-cholesterol levels of FDC group were 26.84 and 62.91 mg/dL, whereas those of FD12S group were 38.02 and 44.16 mg/dL. Supplementation of 12% Koehwa extract powder remarkably increased HDL-cholesterol level and greatly decreased LDLcholesterol level. Atherogenic indices in FD6S and FD12S groups were significantly lower than
those of yje FDG group. The FD12S group supplemented with Koehwa extract showed lower triglyceride concentration than that of the FDC group. These results suggested that dietary supplementation of Koehwa extracts did not have any adversary effect on the hematological variables, but improved the lipid content and reduced hepatic damage of the high fat fed rats.

다국어 초록 (Multilingual Abstract)

The effect of hot water extract of Sophora japonica Linne (Koehwa) flower on lipid content were studied in terms of hematological variables in rats fed with high fat diet. Experimental rats were divided into basal diet only (BDG), high fat diet control (FDC), high fat diet and 6% Sophora japonica extract powder (FD6S), and high fat diet and 12% Sophora japonica extract powder (FD12S) groups. The levels of hematological variables were not significantly different among the four groups, whereas transferrin concentration and glutamic oxaloacetate transaminase (GOT) activity in serum metabolic variables were significantly different. Transferrin concentration was higher in the FD6S and FD12S groups than in BDG and FDC groups. FD6S and FD12S groups
showed significantly lower level of GOT activity. Total cholesterol levels of FD6S and FD12S groups were 220.38 and 205.02 mg/dL in the serum, respectively. Total cholesterol levels of FD6S and FD12S groups were lower than that of FDC group (341.38 mg/dL) and the same level as that of FDG group (216.18 mg/dL). HDL- and LDL-cholesterol levels of FDC group were 26.84 and 62.91 mg/dL, whereas those of FD12S group were 38.02 and 44.16 mg/dL. Supplementation of 12% Koehwa extract powder remarkably increased HDL-cholesterol level and greatly decreased LDLcholesterol level. Atherogenic indices in FD6S and FD12S groups were significantly lower than
those of yje FDG group. The FD12S group supplemented with Koehwa extract showed lower triglyceride concentration than that of the FDC group. These results suggested that dietary supplementation of Koehwa extracts did not have any adversary effect on the hematological variables, but improved the lipid content and reduced hepatic damage of the high fat fed rats.

참고문헌 (Reference)

1 김준한, "홍화씨 추출분말 함유 건강음료의 제조와 항산화성" 한국식품과학회 34 (34): 617-624, 2002

2 최희진, "한국산 배로부터 분리한 Polyphenol 분획물이 지질대사에 미치는 영향" 한국식품영양과학회 33 (33): 299-304, 2004

3 박성혜, "체내 지질 농도 개선에 미치는 차가버섯 음료의 효과" 대한동의병리학회 19 (19): 407-411, 2005

4 차월석, "청피와 모려를 이용한 기능성 건강음료 개발에 관한 연구" 한국생물공학회 17 (17): 503-507, 2002

5 박성혜, "인진쑥 추출물을 함유한 음료가 대학 운동선수의 피로회복 물질과 심박수 및 혈청지질에 미치는 영향" 한국식품영양과학회 33 (33): 839-846, 2004

6 박성혜, "연근의 열수 추출물이 흰쥐의 국소 뇌혈류량과 혈압에 미치는 영향" 동아시아식생활학회 15 (15): 49-56, 2005

7 박성혜, "생식 제품의 섭취가 건강한 성인여성의 영양섭취상태, 식행동, 혈청지질농도 및 건강지표에 미치는 영향" 한국영양학회 36 (36): 49-63, 2003

8 최미숙, "땅두릅뿌리를 이용한 혼합음료가 당뇨 및 고혈압 환자의 혈압과 혈액 성상에 미치는 영향" 한국식품영양학회 15 (15): 165-172, 2002

9 김원희, "돌나물이 난소 절제한 흰쥐의 혈 중 지질 함량에 미치는 영향" 한국식품영양과학회 31 (31): 290-294, 2002

10 Kim MH, "The effects of Daucus carota L. extracts on serum lipid and antioxidative enzyme activity in ovariectomized rats" Kim MH, Ha BJ, and Bae SJ (2000) The effects of Daucus carota L. extracts on serum lipid and antioxidative enzyme activity in ovariectomized rats. Korean J Life Sci 10, 7-13. 10 : 7-13, 2000

11 Kim SJ, "Reduction of mouse body fats by water extract of Pleurotus ostreatus" J Food Sci Nutr 4 : 130-133, 1999

12 Whang WK, "Physiological activities of mixed extracts of Acantopanics senticosi Radicis Cortex and Eucommiae Cortex" Korean J Pharmacogn 27 : 64-75, 1996

13 Wu TS, "Phenylalkynes from Artemisia capillaris" Phytochemistry 47 : 1645-1648, 1998

14 Andrea C, "Novel lipid-lowering properties of Vaccinium myrtillusi leaves, a traditional antidiabetic treatment, in several models of rats dyslipidaemia: A comparison with ciprofibrate" Thrombosis Res 84 : 311-322, 1996

15 Wu TS, "New constituents and antiplatelet aggregation and anti-HIV principles of Artemisia capillaris" Bioorg Med Chem 9 : 77-83, 2001

16 Castelli WP, "Incidence of coronary heart disease and lipoprotein cholesterol levels, The Framingham Study" JAMA 256 : 2835-2838, 1986

17 Lee KN, "In The file of clinical laboratory science" Uhakmunhwasa Press 103-143, 1993

18 Lee KS, "In The encyclopidia of oriental herbal medicine" Jungdam Press 381-383, 1997

19 Kim HY, "Hypocholesterolemic and hypotensive activities of Eucommina ulmoides Oliver" Food Industry Nutr 5 : 27-28, 2000

20 Yang MH, "Green, oolong and black tea extracts modulate lipid metabolism in hyperlipidemia rats fed high-sucrose diet" J Nutr Biochem 12 : 14-20, 2001

21 Shepherd J, "Effects of saturated and polyunsaturated fat diets on the chemical composition and metabolism of low density lipoproteins in man" J Lipid Res 21 : 91-99, 1980

22 Kim JH, "Effects of mugwort, dried orange peel and Duchung on lipid metabolism in hyperlipidemia rats" Korean J Nutr 30 : 895-903, 1997

23 Park PS, "Effects of Diocorea batatas and Gastrodia rhizoma on fatly acid compositions of serum, liver and brain in rats" Korean J Life Sci 11 : 83-92, 2001

24 Hwang GH, "Effects of Coriandrum sativum L. on lipid metabolism in rats with hypertriglyceridemic diet" Nutritional Science 4 : 13-19, 2001

25 Andorson JA, "Diabetes mellitus: Medical nutrition therapy. In Modern nutrition in health and disease" Lea and Febriger 1045-, 2006

26 Sharrett AR, "Coronary heart disease prediction from lipoprotein cholesterol levels, triglycerides, lipoprotein(a), apolipoproteins A-and B, and HDL density subfractions: the atherosclerosis risk in communities (ARIC) study" Circulation 104 : 1108-1113, 2001

27 Mettson FH, "Comparison of effects of dietary saturated monounsaturated and polyunsaturated fatty acid on plasma lipids and lipoproteins in man" J Lipid Res 26 : 194-200, 1985