면역매개성 중이염에서 종양괴사인자-α억제제와 Oxatomide의 효과 = Effect of Inhibitor of TNF-α and Oxatomide on Experimental Immune Mediated Otitis Media with Effusion

다국어 초록 (Multilingual Abstract)

Background and Objectives：Local imune response, one of the pathogenesis of middle ear efusion (MEE) is associated with -tion of ME. The purpose of this study was to determine the efects of TNF-α antagonist and oxatomide on the outcome of immune mediated otitis media with efusion (OME) in rats. Materials and Method：Otitis media was induced by injecting KLH (Keyhole lympet hemocyanin) transtympanicaly 7 days after systemic imunization. Phosphate-buffered saline solution was used as control. Other groups were pretreated with TNF-α antagonist ( ) or oxatomide respecti-vely before transtympanic injection of KLH. Seventy-two hours after the transtympanic injection, temporal bones in each group were examined histopathologically and vascular permeability of the middle ear mucosa was measured by the Evans blue vital dye technique. Results：In the KLH, sTNF RI and oxatomide groups, ME was developed in 83%, 0%, 66% of the ears, respectively. bility as compared with KLH group and those parameters of sTNF RI group showed lower values than those of oxatomide group. Conclusion：Transtympanic administration of sTNF RI and oxatomide appears to supres the development of imune mediated OME. In terms of inhibiting ME, sTNF RI was more efective than oxatomide. This study sugests that TNF-α antagonist and oxatomide may have a adjunctive role in the treatment and prevention of otitis media with effusion.

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