성별에 따른 트레드밀 달리기가 노화 쥐의 공간기억력에 미치는 영향을 연구하였다. 2개월 된 암컷 쥐와 수컷 쥐를 젊은 쥐로 하였고, 15개월 된 암컷 쥐와 수컷 쥐를 노화 쥐로 하였다. 실험...
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https://www.riss.kr/link?id=A99950069
2012
Korean
Aging ; Treadmill exercise ; Spatial memory ; Neurogenesis ; Apoptosis ; 노화 ; 트레드밀 달리기 ; 공간기억력 ; 신경세포 생성 ; 세포사멸
KCI등재후보
학술저널
51-60(10쪽)
2
0
상세조회0
다운로드국문 초록 (Abstract)
성별에 따른 트레드밀 달리기가 노화 쥐의 공간기억력에 미치는 영향을 연구하였다. 2개월 된 암컷 쥐와 수컷 쥐를 젊은 쥐로 하였고, 15개월 된 암컷 쥐와 수컷 쥐를 노화 쥐로 하였다. 실험...
성별에 따른 트레드밀 달리기가 노화 쥐의 공간기억력에 미치는 영향을 연구하였다. 2개월 된 암컷 쥐와 수컷 쥐를 젊은 쥐로 하였고, 15개월 된 암컷 쥐와 수컷 쥐를 노화 쥐로 하였다. 실험동물은 젊은 암컷 대조군(N=6), 젊은 암컷 운동군(N=6), 젊은 수컷 대조군(N=6), 젊은 수컷 운동군(N=6), 노화 암컷 대조군(N=6), 노화 암컷 운동군(N=6), 노화 수컷 대조군(N=6), 노화 수컷 운동군(N=6)의 8군으로 나누었다. 운동군은 소형동물용 트레드밀에서 하루 일회 30분간 4주 동안 트레드밀 달리기를 실시하였다. 노화 쥐는 젊은 쥐와 비교하였을 때 공간기억력의 감퇴를 나타내었고 해마에서 신경세포 생성은 억제된 반면 세포 사멸은 증가되었다. 노화 쥐에서 트레드밀 달리기를 시행하였을 때, 공간 기억력의 감퇴가 억제되었고 해마의 신경세포 생성은 증가된 반면 세포사멸은 억제되었다. 해마에서의 myostatin과 follistatin 발현은 뇌화 쥐에서 억제되었으나, 트레드밀 달리기에 의하여 증가되었다. 그러나 트레드밀 달리기의 이러한 효과는 성별에 따른 차이는 나타나지 않았다. 본 연구를 통하여 트레드밀 달리기는 해마에서 myostatin과 follistatin의 발현을 억제함으로써 신경세포 생성을 증가시켜 노화에 의한 기억력 감퇴를 경감시킴을 알 수 있었다.
다국어 초록 (Multilingual Abstract)
We investigated the effects of treadmill exercise according to gender on spatial memory in old aged rats. Two month-old female rats and male rats were used as the young-aged groups, meanwhile 16-month-old female rats and male rats were used as the old...
We investigated the effects of treadmill exercise according to gender on spatial memory in old aged rats. Two month-old female rats and male rats were used as the young-aged groups, meanwhile 16-month-old female rats and male rats were used as the old-aged groups. The rats were divided into 8 groups (N=6 in each group): young-aged female control group, young-aged female exercise group, young-aged male control group, young-aged male exercise group, old-aged female control group, old-aged female exercise group, old-aged male control group, old-aged male exercise group. The rats in the exercise groups were forced to run on a motorized treadmill for 30 min once a day for 4 weeks. In old-aged rats, spatial memory was disturbed, in contrast treadmill exercise improved spatial memory in the old-aged rats. Neurogenesis in the hippocampus was decreased and apoptosis was increased in the old-aged rats. In contrast, treadmill exercise increased neurogensis and decreased apoptosis in the old-aged rats. Myostatin and follistatin expressions in the hippocampus were increased in the old-aged rats. Treadmill exercise suppressed myostatin and follistatin expressions in the old-aged rats. There was no gender difference in these effects of treadmill exercise. We showed that treadmill exercise is a very useful strategy for ameliorating age-induced memory loss by increasing neurogenesis through suppressing myostatin and follistatin expressions. (Korean J Str Res 2012;20:51∼60)
참고문헌 (Reference)
1 Jarrard LE, "What does the hippocampus really do?" 71 : 1-10, 1995
2 Jee-Sang Yoon, "Various Types of Stress Deteriorate Spatial Memory through Inhibition of Cell Proliferation in the Hippocampus of Rats" 대한스트레스학회 19 (19): 243-251, 2011
3 Il-Gyu Ko, "Treadmill Exercise Reduces Lipopolysaccharide-induced Apoptotic Neuronal Cell Death in the Hippocampus of the Young and Old Rats" 대한스트레스학회 19 (19): 97-105, 2011
4 Wachs FP, "Transforming growth factor-β1 is a negative modulator of adult neurogenesis" 65 : 358-370, 2006
5 Pollack M, "The role of apoptosis in the normal aging brain, skeletal muscle, and heart" 959 : 93-107, 2002
6 Patrylo PR, "The effects of aging on dentate circuitry and function" 163 : 679-696, 2007
7 Gould E, "Stress and hippocampal neurogenesis" 46 : 1472-1479, 1999
8 Sun XQ, "Simulated weightlessness aggravates hypergravity-induced impairment of learning and memory and neuronal apoptosis in rats" 199 : 197-202, 2009
9 Lee SJ, "Regulation of myostatin activity and muscle growth" 98 : 9306-9311, 2001
10 West MJ, "Regionally specific loss of neurons in the aging human hippocampus" 14 : 287-293, 1993
1 Jarrard LE, "What does the hippocampus really do?" 71 : 1-10, 1995
2 Jee-Sang Yoon, "Various Types of Stress Deteriorate Spatial Memory through Inhibition of Cell Proliferation in the Hippocampus of Rats" 대한스트레스학회 19 (19): 243-251, 2011
3 Il-Gyu Ko, "Treadmill Exercise Reduces Lipopolysaccharide-induced Apoptotic Neuronal Cell Death in the Hippocampus of the Young and Old Rats" 대한스트레스학회 19 (19): 97-105, 2011
4 Wachs FP, "Transforming growth factor-β1 is a negative modulator of adult neurogenesis" 65 : 358-370, 2006
5 Pollack M, "The role of apoptosis in the normal aging brain, skeletal muscle, and heart" 959 : 93-107, 2002
6 Patrylo PR, "The effects of aging on dentate circuitry and function" 163 : 679-696, 2007
7 Gould E, "Stress and hippocampal neurogenesis" 46 : 1472-1479, 1999
8 Sun XQ, "Simulated weightlessness aggravates hypergravity-induced impairment of learning and memory and neuronal apoptosis in rats" 199 : 197-202, 2009
9 Lee SJ, "Regulation of myostatin activity and muscle growth" 98 : 9306-9311, 2001
10 West MJ, "Regionally specific loss of neurons in the aging human hippocampus" 14 : 287-293, 1993
11 Siriett V, "Prolonged absence of myostatin reduces sarcopenia" 209 : 866-873, 2006
12 Lemaire V, "Prenatal stress produces learning deficits associated with an inhibition of neurogenesis in the hippocampus" 97 : 11032-11037, 2000
13 Bilezikjian LM, "Pituitary follistatin and inhibin subunit messenger ribonucleic acid levels are differentially regulated by local and hormonal factors" 137 : 4277-4284, 1996
14 Fordyce, DE, "Physical activity enhances spatial learning performance with n associated alteration in hippocampal protein kinase C activity in C57BL/6 and BA/2 mice" 619 : 111-119, 1993
15 Fabel K, "Physical activity and the regulation of neurogenesis in the adult and aging brain" 10 : 59-66, 2008
16 Kuhn HG, "Neurogenesis in the dentate gyrus of the adult rat: age‐related decrease of neuronal progenitor proliferation" 16 : 2027-2033, 1996
17 Eriksson PS, "Neurogenesis in the adult human hippocampus" 4 : 1313-1317, 1998
18 Bizon JL, "Neurogenesis in a rat model of age related cognitive decline" 3 : 227-234, 2004
19 Artaza JN, "Myostatin inhibits myogenesis and promotes adipogenesis in C3H 10T(1/2) mesenchymal multipotent cells" 146 : 3547-3557, 2005
20 Kambadur R, "Mutations in myostatin (GDF8) in double-muscled Belgian Blue and Piedmontese cattle" 7 : 910-916, 1997
21 Fuchs E, "Mini-review: in vivo neurogenesis in the adult brain: regulation and functional implications" 12 : 2211-2214, 2000
22 Albeck DS, "Mild forced treadmill exercise enhances spatial learning in the aged rat" 168 : 345-348, 2006
23 Reed JC, "Mechanisms of apoptosis" 157 : 1415-1430, 2000
24 Drapeau E, "Learning-induced survival of new neurons depends on the cognitive status of aged rats" 27 : 6037-6044, 2007
25 Andreasson K, "Induction of b-A activin expression by synaptic activity and during neocortical development" 69 : 781-796, 1995
26 Inokuchi K, "Increase in activin bA mRNA in rat hippocampus during long-term potentiation" 382 : 48-52, 1996
27 Small SA, "Imaging hippocampal function across the human life span: is memory decline normal or not?" 51 : 290-295, 2002
28 Gavrieli Y, "Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation" 119 : 493-501, 1992
29 Galea LA, "Gonadal hormone modulation of hippocampal neurogenesis in the adult" 16 : 225-232, 2006
30 Perfilieva E, "Gender and strain influence on neurogenesis in dentate gyrus of young rats" 21 : 211-217, 2001
31 Patel K, "Follistatin" 30 : 1087-1093, 1998
32 Cotman CW, "Exercise: a behavioral intervention to enhance brain health and plasticity" 25 : 295-301, 2002
33 van Praag H, "Exercise enhances learning and hippocampal neurogenesis in aged mice" 25 : 8680-8685, 2005
34 Johansson BB, "Environment, social interaction, and physical activity as determinants of functional outcome after cerebral infarction in the rat" 139 : 322-327, 1996
35 Arida RM, "Effects of different types of physical exercise on the staining of parvalbumin-positive neuron in the hippocampal formation of rats with epilepsy" 31 : 814-822, 2007
36 McKoy G, "Developmental expression of myostatin in cardiomyocytes and its effect on foetal and neonatal rat cardiomyocyte proliferation" 74 : 304-312, 2007
37 Buckwalter MS, "Chronically increased transforming growth factor-β1 strongly inhibits hippocampal neurogenesis in aged mice" 169 : 154-164, 2006
38 Kerr JF, "Apoptosis: a basic biological phenomenon with wide ranging implications in tissue kinetics" 26 : 239-257, 1972
39 Li Y, "Apoptosis and protein expression after focal cerebral ischemia in rat" 765 : 301-312, 1997
40 Is M, "Age‐related changes in the rat hippocampus" 15 : 568-574, 2008
41 Mattson MP, "Ageing and neuronal vulnerability" 7 : 278-294, 2006
42 Kim YP, "Age-dependence of the effect of treadmill exercise on cell proliferation in the dentate gyrus of rats" 355 : 152-154, 2004
43 Colcombe SJ, "Aerobic fitness reduces brain tissue loss in aging humans" 58 : M176-M180, 2003
44 Shoji-Kasai Y, "Activin increases the number of synaptic contacts and the length of dendritic spine necks by modulating spinal actin dynamics" 120 : 3830-3837, 2007
45 Kogure K, "A single intraportal administration of follistatin accelerates liver regeneration in partially hepatectomized rats" 108 : 1136-1142, 1995
한국형 마음챙김기반 스트레스감소 프로그램(K-MBSR)이 암환자의 혈압, 심리적 증상 및 삶의 질에 미치는 효과
학술지 이력
연월일 | 이력구분 | 이력상세 | 등재구분 |
---|---|---|---|
2022 | 평가예정 | 재인증평가 신청대상 (재인증) | |
2019-01-01 | 평가 | 등재학술지 유지 (계속평가) | |
2017-03-01 | 학술지명변경 | 외국어명 : THE KOREAN JOURNAL OF STRESS RESEARCH -> stress | |
2016-01-01 | 평가 | 등재학술지 선정 (계속평가) | |
2015-01-01 | 평가 | 등재후보학술지 유지 (계속평가) | |
2013-01-01 | 평가 | 등재후보학술지 유지 (기타) | |
2012-01-01 | 평가 | 등재후보 1차 FAIL (기타) | |
2011-01-01 | 평가 | 등재후보학술지 유지 (등재후보2차) | |
2010-01-01 | 평가 | 등재후보 1차 PASS (등재후보1차) | |
2009-01-01 | 평가 | 등재후보학술지 유지 (등재후보1차) | |
2007-01-01 | 평가 | 등재후보학술지 선정 (신규평가) | |
2006-06-30 | 학회명변경 | 한글명 : 대한신심스트레스학회 -> 대한스트레스학회영문명 : The Korean Society Of Biosociobehavioral Science -> The Korean Society of Stress Medicine | |
2006-06-27 | 학회명변경 | 한글명 : 대한신심스트레스학회 -> 대한스트레스학회영문명 : The Korean Society Of Biosociobehavioral Science -> The Korean Society of Stress Medicine |
학술지 인용정보
기준연도 | WOS-KCI 통합IF(2년) | KCIF(2년) | KCIF(3년) |
---|---|---|---|
2016 | 1.76 | 1.76 | 1.63 |
KCIF(4년) | KCIF(5년) | 중심성지수(3년) | 즉시성지수 |
1.61 | 1.44 | 2.211 | 0.2 |