Lysophosphatidylglycerol inhibits formyl peptide receptor like-1-stimulated chemotactic migration and IL-1β production from human phagocytes

다국어 초록 (Multilingual Abstract)

In this study, we observed that lysophosphatidylglycerol
(LPG) completely inhibited a formyl peptide receptor
like-1 (FPRL1) agonist (MMK-1)-stimulated chemotactic
migration in human phagocytes, such as neutrophils
and monocytes. LPG also dramatically inhibited
IL-1β production by another FPRL1 agonist serum
amyloid A (SAA) in human phagocytes. However,
LPG itself induced intracellular calcium increase and
superoxide anion production in human phagocytes.
Keeping in mind that phagocytes migration and IL-1β
production by FPRL1 are important for the induction
of inflammatory response, our data suggest that LPG
can be regarded as a useful material for the modulation
of inflammatory response induced by FPRL1 activation.

다국어 초록 (Multilingual Abstract)

In this study, we observed that lysophosphatidylglycerol
(LPG) completely inhibited a formyl peptide receptor
like-1 (FPRL1) agonist (MMK-1)-stimulated chemotactic
migration in human phagocytes, such as neutrophils
and monocytes. LPG also dramatically inhibited
IL-1β production by another FPRL1 agonist serum
amyloid A (SAA) in human phagocytes. However,
LPG itself induced intracellular calcium increase and
superoxide anion production in human phagocytes.
Keeping in mind that phagocytes migration and IL-1β
production by FPRL1 are important for the induction
of inflammatory response, our data suggest that LPG
can be regarded as a useful material for the modulation
of inflammatory response induced by FPRL1 activation.

참고문헌 (Reference)

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