인체면역결핍바이러스 감염 환자에서 발생한 이비인후과 질환의 분석 = Analysis of Otorhinolaryngologic Disease in Patients with Human Immunodeficiency Virus Infection

다국어 초록 (Multilingual Abstract)

Background and Objectives：As human immunodeficiency virus (HIV) infection increases in prevalence and new medical
therapies prolong the survival of HIV-infected patients, otolaryngologists will see a larger number of patients with head and neck
manifestations of HIV infection. The aims of study were to evaluate the various otorhinolaryngologic diseases and to analyze the
useful markers for predicting immune function in HIV-infected patients. Subjects and Method：Of 380 HIV-infected patients,
40 patients (10.5%；39 males and 1 female, age ranging from 23 to 55) were referred to otorhinolaryngologists. Spectrum of
disease and correlation between various surrogate markers (HIV RNA, leukocyte count, neutrophil, lymphocyte, CD3, CD4,
CD8 T cell percentage and count, CD4/CD8 ratio) and risk of infectious otorhinolaryngologic diseases were analyzed. Results：
Thirty-three patients (82.5%) were infectious, 6 patients (15.0%) had non-infectious diseases and 1 patient (2.5%) malignancy.
In otologic diseases, acute otitis media and chronic otitis media were frequently found in the mentioned order. In rhinologic diseases,
rhinosinusitis and vestibulitis were frequently found in the mentioned order, with one primary extra nodal non-Hodgkin’s
lymphoma. In laryngologic diseases, pharyngolaryngitis, oral candidiasis, stomatitis were frequently found. In the surrogate markers
of immune function, CD4 percentage, CD4 count and CD4/CD8 ratio were found significantly lower in the infectious diseases
than in the non-infectious disease. Conclusion：Of HIV-infected patients, 10.5% had seen an otolaryngologist, and the
majority had infectious diseases. The risk of infectious diseases was strongly correlated with the CD4 percentage, count and
CD4/CD8 ratio.

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