식품 섭취와 인지기능장애의 관계에 대한 체계적 문헌고찰과 메타분석

다국어 초록 (Multilingual Abstract)

This systematic review and meta-analysis aimed to determine whether food intake is effective in preventing diseases related to cognitive impairment. We searched English databases namely MEDLINE, PubMed and ScienceDirect from 2000 to May 2020, and Korean databases namely RISS, KISS, and DBPIA from 1990 to May 2020. We divided the data into 15 groups using the food group classification of the Korean Nutrition Society (KNS). The effect size (Cohen's d) was estimated using a random-effect model, and a 95% confidence interval was calculated for each study. We included 17 cross-sectional studies and 7 cohort studies which involved 45,115 participants. As a result of analyzing the subgroups in the Asian population of both sexes, it was observed that grain intake has a protective effect against cognitive impairment. For females, pulses and fish also have a protective role against cognitive impairment. In the case of seaweed, a negative relationship was found with a moderate protective effect against cognitive impairment (Cohen's d:-0.533, 95% CI: -0.939, -0.126; p=0.010) in Korean studies. Dairy products are associated with an increased risk of cognitive impairment in the American and European population but drinking alcohol is associated with a lower impairment risk. These results provide a basis for formulating the dietary guidelines for preventing dementia for each country.

목차 (Table of Contents)

• Ⅰ. 서 론 8
• 1. 연구배경 및 필요성 8
• 2. 연구목적 10
• Ⅱ. 문헌고찰 11
• 1. 용어정의 11
• 2. 치매의 진단검사 및 기준 11
• 3. 체계적 문헌고찰과 메타분석 14
• Ⅲ. 연구방법 21
• 1. 연구설계 21
• 2. 문헌검색 21
• 3. 문헌선정 22
• 4. 자료추출 22
• 5. 식품군 분류 22
• 6. 질 평가 23
• 7. 통계분석 27
• Ⅳ. 결과 및 고찰 28
• 1. 체계적 문헌고찰 28
• 1) 체계적 문헌고찰 28
• 2) 식품 섭취 평가와 인지기능진단 검사 및 기준 29
• 2. 메타분석 39
• 1) 식품 섭취가 인지기능장애에 영향을 미치는 효과크기 39
• 2) 식품군 내 하위그룹 분석결과 41
• (1) 곡류 45
• (2) 전분류 47
• (3) 콩류 48
• (4) 채소류 51
• (5) 과일류 52
• (6) 육류 53
• (7) 계란류 54
• (8) 어패류 55
• (9) 해조류 58
• (10) 우유 및 유제품류 60
• (11) 유지류 61
• (12) 견과류 63
• (13) 알코올류 65
• (14) 무알코올성 음료류 68
• (15) 단순당류 69
• 5. 출판 편의 진단 70
• Ⅵ. 결 론 74
• Ⅶ. 참 고 문 헌 76
• ABSTRACT 84