<P><I>Aim:</I> To investigate the physicochemical stability, pharmacokinetics (PK), and biodistribution of paclitaxel (PTX) from paclitaxel solid dispersion (PSD) prepared by supercritical antisolvent (SAS) process.</P><P>...
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https://www.riss.kr/link?id=A107749564
2011
-
SCOPUS,SCIE
학술저널
628-637(10쪽)
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
<P><I>Aim:</I> To investigate the physicochemical stability, pharmacokinetics (PK), and biodistribution of paclitaxel (PTX) from paclitaxel solid dispersion (PSD) prepared by supercritical antisolvent (SAS) process.</P><P>...
<P><I>Aim:</I> To investigate the physicochemical stability, pharmacokinetics (PK), and biodistribution of paclitaxel (PTX) from paclitaxel solid dispersion (PSD) prepared by supercritical antisolvent (SAS) process.</P><P><I>Methods:</I> Physicochemical stability was performed in accelerated (40°째C 70 ??±짹 ??5% RH) and stress (60°째C) storage conditions for a period of 6 months and 4 weeks, respectively. PK and biodistribution studies were performed in rats following i.v. administration of PTX equivalent to 6 and 12 ??mg/kg formulations.</P><P><I>Results:</I> Physical stability of PSD showed excellent stability with no recrystallization of the amorphous form. Chemical stability of PSD in terms of % PTX remaining was 98.2 ??±짹 ??0.6% at 6 months and 97.9 ??±짹 ??0.3% at 4 weeks of accelerated and stress conditions, respectively. The PK study showed a nonlinear increase in AUC with increasing dose, that is, 100% increase in dose (from 6 to 12 ??mg/kg) resulted in 405.90% increase in AUC. Unlike PK study, the organ distribution study of PTX from PSD showed linear relationship with dose escalation. The order of organ distribution of PTX from highest to lowest for both PSD and Taxol<SUP>®짰</SUP> was liver>kidney>lung>brain.</P><P><I>Conclusions:</I> This study demonstrated excellent physicochemical stability with insight information on the PK and biodistribution of PTX from PSD prepared by SAS process.</P>