전두부에 발생한 랑게르한스세포 조직구증의 치험례 = A Case Report of Langerhans Cell Histiocytosis of Frontal Area

다국어 초록 (Multilingual Abstract)

Purpose: Langerhans cell histiocytosis is a heterogenous
group of Langerhans cell proliferative disorders and includes
eosinophilic granuloma, Letterer-Siwe diseases, and Hand-
Schuller Christian disease. We report a case of eosinophilic
granuloma on frontal area.
Methods: A 17-year-old male presented with swelling and
tenderness on Lt. frontal and periorbital area. CT and MRI
showed a 33 × 25 mm sized mass that involved Lt. frontal
calvarium, frontotemporal meninges, and orbital roof.
Results: Total excision of the mass and adjacent soft
tissue, calvarium, and orbital roof was performed. Orbital
roof defect was reconstructed with absorbable plate and
calvarial defect was done with outer cortex of temporal bone
flap. The histology revealed proliferation of histiocytes and
eosinophils. Immunologically, these histiocytic cells expressed
S-100 protein and CD1a. The patient is currently
taking conservative treatment.
Conclusion: The severity of these disease and their
prognosis and treatments are various. For unifocal cranial
Langerhans cell histiocytosis, complete excision is the
treatment of choice. We report this case with review of
literature.

참고문헌 (Reference)

1 이백수, "랑거한스세포 조직구증식증의 치험례" 대한악안면성형재건외과학회 26 (26): 593-597, 2004

2 김일만, "두경부를 침범한 랑게르한스 세포 조직구증의 치료" 대한신경외과학회 32 (32): 553-558, 2002

3 Krishna H, "Solitary Langerhans-cell histiocytosis of the clivus and sphenoid sinus with parasellar and petrous extensions: case report and a review of literature" 62 : 447-, 2004

4 Burn DJ, "Langerhans` cell histiocytosis and the nervous system" 239 : 345-, 1992

5 Modan-Moses D, "Langerhans' cell histiocytosis presenting as intracranial hypertension" 16 : 414-, 2001

6 Cho YB, "A case of langerhans cell histiocytosis of bilateral temporal bone" 44 : 206-, 2001