Parathion을 투여(投與)한 Rat의 혈청(血淸), 척수(脊髓) 및 뇌(腦) Cholinesterase 활성도(活性度)의 변동(變動) 조사(調査) = Changes in the Activities of Cholinesterase in Serum, Brain and Spinal cord Injection of Parathion in Rats

다국어 초록 (Multilingual Abstract)

Parathion is widely used in agriculture, but it is highly toxic and now clear that parathion behaves like a cholinergic drug by inhibiting the enzyme cholinesterase. In order to know acute toxicity and the changes of cholinesterase activity according to time lapsed in Sprague-Dawley rats injected single with half dose to LD50 of parathion, cholinesterase activities in serum, spinal cord, whole brain and median lethal dose between sex difference were investigated. The results obtained were summerized as follows; 1. LD50 values of parathion given intraperitoneally to male and female rats were 10.5mg/kg(95% confidence limits, 6.6-16.8mg / kg) and 3.3mg / kg (95% confidence limits, 1.9-5.6mg / kg). 2. The inhibition rate of cholinesterase activities in serum of parathion-injected rats according to time lapsed were peakly decreased to 35.4%(male) and 32.4%(female) after 1 hour in comparison to control group, but cholinesterase activities were completely recovered after 48 hours. 3. The inhibition rate of cholinesterase activities in spinal cord of parathion-injected rats according to time lapsed were peakly decreased to 31.1%(male) and 36.3%(female) after 30 minutes in comparison to control group, but cholinesterase activities were completely recovered after 48 hours. 4. The inhibition rate of cholinesterase activities in whole brain of parathion-injected rats according to time lapsed were peakly decreased to 32.2%(male) and 42.6%(female) after 1 hour in comparison to control group, but cholinesterase activities were completely recovered after 48 hours.