Atropo‐enantioselective C−H functionalization reactions are largely limited to the dynamic kinetic resolution of biaryl substrates through the introduction of steric bulk proximal to the axis of chirality. Reported herein is a highly atropo‐enan...
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https://www.riss.kr/link?id=O120453440
2018년
-
1433-7851
1521-3773
SCI;SCIE;SCOPUS
학술저널
11040-11044 [※수록면이 p5 이하이면, Review, Columns, Editor's Note, Abstract 등일 경우가 있습니다.]
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
Atropo‐enantioselective C−H functionalization reactions are largely limited to the dynamic kinetic resolution of biaryl substrates through the introduction of steric bulk proximal to the axis of chirality. Reported herein is a highly atropo‐enan...
Atropo‐enantioselective C−H functionalization reactions are largely limited to the dynamic kinetic resolution of biaryl substrates through the introduction of steric bulk proximal to the axis of chirality. Reported herein is a highly atropo‐enantioselective palladium(0)‐catalyzed methodology that forges the axis of chirality during the C−H functionalization process, enabling the synthesis of axially chiral dibenzazepinones. Computational investigations support experimentally determined racemization barriers, while also indicating C−H functionalization proceeds by an enantio‐determining CMD to yield configurationally stable eight‐membered palladacycles.
A barrier thing: A palladium‐catalyzed atropo‐enantioselective route towards axially chiral dibenzazepinones has been developed. The TADDOL‐derived phosphoramidite ligand L* provides high levels of enantiocontrol. Computational investigations provide information on racemization barriers and suggest an enantiodetermining C−H functionalization event. dba=dibenzylideneacetone.
Site‐Specific Labeling of Affimers for DNA‐PAINT Microscopy
Remote Control of Anion–π Catalysis on Fullerene‐Centered Catalytic Triads