Capsicum annuum L. cultivar DANGJO Amelorated Type 2 Diabetes Induced by High-fat Diet and Streptozotocin

다국어 초록 (Multilingual Abstract)

In this study, we evaluated the effect of the powder of Capsicum annuum L. cultivar DANGJO (DJP) on ameliorating type 2 diabetes induced by high-fat diet (HFD) and streptozotocin (STZ) in rats. Here, we found that oral administration of DJP significantly decreased the non-fasting blood glucose level as well as fasting blood glucose level in HFD-STZ induced type 2 diabetes rats. Interestingly, the administration of the powder of green hot pepper (GHP) and green sweet pepper (GSP) did not show the effect on the blood glucose level. In addition, DJP administration reduced the level of glycated hemoglobin (HbA1c), a representative marker of diabetes, and ameliorated the insulin resistance. Quercitrin, one of the major phytochemicals identified in DJP, was administrated at the same amount as that in DJP showed the regulatory effect on blood glucose level, indicating that quercitrin may be the key ingredient in ameliorating type 2 diabetes in DJP. Taken together, DJP can be considered as a potent functional food in preventing type 2 diabetes.