<P>Two new α-pyrones, dothideopyrones E (<B>1</B>) and F (<B>2</B>), were isolated from a culture of the endolichenic fungus <I>Dothideomycetes</I> sp. EL003334. Their structures were elucidated by spect...
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https://www.riss.kr/link?id=A107650726
2018
-
SCI,SCIE,SCOPUS
학술저널
1084-1088(5쪽)
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
<P>Two new α-pyrones, dothideopyrones E (<B>1</B>) and F (<B>2</B>), were isolated from a culture of the endolichenic fungus <I>Dothideomycetes</I> sp. EL003334. Their structures were elucidated by spect...
<P>Two new α-pyrones, dothideopyrones E (<B>1</B>) and F (<B>2</B>), were isolated from a culture of the endolichenic fungus <I>Dothideomycetes</I> sp. EL003334. Their structures were elucidated by spectroscopic data analysis. Their absolute configurations were established by the modified Mosher’s method. Compound <B>2</B> inhibited nitric oxide (NO) production with IC<SUB>50</SUB> values of 15.0 ± 2.8 μM in lipopolysaccharide (LPS)-induced BV2 cells. Compound <B>2</B> diminished the protein expression levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Additionally, <B>2</B> decreased the mRNA expression levels of pro-inflammatory cytokines, such as tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-6.</P>
[FIG OMISSION]</BR>
Total Synthesis of Gramistilbenoids A, B, and C