早角刺의 消炎作用에 對한 實驗的 硏究 : 托裏消毒飮과 瓜蔞牛蒡湯의 加減에 따른 效能比較 Focussed on Takrisodokum and Kwaluubangtang = Study on the Antiinflammatory Effect of Gleditschiae Spina

다국어 초록 (Multilingual Abstract)

The inhibitory effects of Gleditschiae Spina, Gleditschia saponin, two complex prescriptions such as Takrisodokum and Kwaluubangtang, which contain Gleditschiae Spina, and their altered prescriptions on the activity of cyclooxygenase in vitro were investigated.
The water extract of Gleditschiae Spina and Gleditschia saponin markedly inhibited the cyclooxygenase activity by 59% and 67% , respectively, at a concentration of 1㎎/㎖, on the other hand, Takrisodokum and Kwaluubangtang showed 15% and 7% inhibition, respectively. The extracts with the subst
raction of Gleditschiae Spina and/or Platycodi Radix inhibited to a much smaller extent than Takrisodokum. However, in case of the extracts with the substraction of Gleditschiae Spina and/or Trichosanthis Semen, only one prescription, which does not contain Trichosanthis Semen, exhibited the same inhibition as Takrisodokum.
From above results, Gleditschiae Spina was found to be most import
ant for the effect of Takrisodokum and Kwaluubangtang on there antiinflammatory action.
Instead of Gleditschiae Spina another parts of this plant were added to both complex prescriptions and tested according to above methods, indicating that Gleditschiae Spina is more important than a
nother parts for both prescriptions. When the administered dose of Gleditschiae Spina is increased (twofold and threefold) in both complex prescriptions, the inhibitory effect in Takrisodokum was diminished, however, the effect in Kwaluubangtang was increased.