P158 A study of the changes of Th17 cells and regulatory T cells in herpes zoster = P158 A study of the changes of Th17 cells and regulatory T cells in herpes zoster

다국어 초록 (Multilingual Abstract)

Background: Although the mechanisms involved in reactivation of latent varicella-zoster virus (VZV) are unclear, the immunosuppression is an important factor involved in reactivation. CD4+CD25+Foxp3+ regulatory T cells (Treg) and T-hepler 17 cells (Th17) are closely associated with a various viral infections. Objectives: In this study, we aimed to investigate the changes of Treg cells and Th17 cells in herpes zoster patients. Methods: The percentage of circulating Th17 cells, Treg cells, and ratio of Th17 to Treg cells were examined in herpes zoster patients and controls. The changes of Treg and Th17 cells between pre-treatment and post-treatment and clinical parameters in herpes zoster patients were also analyzed. Results: There were significant difference in circulating Th17 cells proportion and ratio of Th17 to Treg cells in herpes zoster patients compare to control. However, there was no significant difference in Treg cells proportion in herpes zoster patients compared to control. There was no significant difference in Treg, Th17 cells and ratio of Th17 to Treg cells between pre-treatment and post-treatment. There was significant correlation between body surface area (BSA) and Treg cells, Th17 and the ratio of Th17 to Treg cells. Conclusion: These findings provide that there is an imbalance in Th17 and Treg cells associated with reactivation of VZV, which may contribute to pathogenesis of herpes zoster.