Preparation and activity evaluation of chrysin-b-Dgalactopyranoside

다국어 초록 (Multilingual Abstract)

Chrysin-b-D-galactopyranoside was efficiently synthesized, evaluated for its inhibitory activities against H22 cell lines compared with chrysin, the scavenging of hydroxyl radical, DPPH radical and superoxide anion, inhibitory effect against bacteria and fungi. The structures of all compounds were fully characterized by spectroscopic data (NMR, MS). The anti-tumor, antioxidant and antimicrobial activities of chrysin-b-D-galactopyranoside were proved to be enhanced significantly compared with chrysin.

참고문헌 (Reference)

1 Sargent JM, "The use of the MTT assay to study drug resistance in fresh tumour samples" 161 : 13-25, 2003

2 Lo¨nn H, "Synthesis of a tri-and a hepta-saccharide which contain a-L-fucopyranosyl groups and are part of the complex type of carbohydrate moiety of glycoproteins" 139 : 105-113, 1985

3 Bregant S, "Synthesis of a highly hydrophobic dimeric Lewis X containing glycolipid: a model for the study of homotypic carbohydrate–carbohydrate interaction" 16 : 757-, 1999

4 Park H, "Synthesis and inhibition of PGE 2 production of 6, 8-disubstituted chrysin derivatives" 40 : 943-948, 2005

5 Zhu Z-Y, "Synthesis and antitumor activity evaluation of chrysin derivatives" 75 : 297-300, 2014

6 Bekhit AA, "Synthesis and antimicrobial evaluation of chalcone and syndrome derivatives of 4(3H)-quinazolinone" 140 : 297-301, 2001

7 Tran T-D, "Synthesis and antibacterial activity of some heterocyclic chalcone analogues alone and in combination with antibiotics" 17 (17): 6684-6696, 2012

8 Zheng C-J, "Synthesis and anti-bacterial activity of some heterocyclic chalcone derivatives bearing Thiofuran, Furan, and Quinoline Moieties" 344 : 689-695, 2011

9 Gourier C, "Specific and non specific interactions involving Le X determinant quantified by lipid vesicle micromanipulation" 21 : 165-174, 2004

10 Mentzer C, "Preparation and pharmacodynamic action of some flavones" 35 : 501-506, 1953

11 Singh N, "Free radical scavenging activity of an aqueous extract of potato peel" 85 : 611-, 2004

12 Cheng CL, "Bacteriostasic activity of anthocyanin of Malva sylvestris" 17 : 83-85, 2006

13 Amarowicz R, "Antioxidant activity of various fractions of non-tannin phenolics of canola hulls" 48 : 2755-2759, 2000

14 Alluis B, "Acylated flavone glucosides: Synthesis, conformational investigation, and complexation properties" 82 : 2201-2212, 1999