Novel Zn(II) complexes with the general formula: [Zn(furo)2(L)n], n = 1 or 2, (furo = furosemide = (4‐chloro‐2‐(furan‐2‐ylmethylamino)‐5‐sulfamoylbenzoic acid) were prepared. The complexes [Zn(furo)2(MeOH)2] (1; MeOH = methanol),...
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https://www.riss.kr/link?id=O115091284
2019년
-
0268-2605
1099-0739
SCI;SCIE;SCOPUS
학술저널
n/a-n/a [※수록면이 p5 이하이면, Review, Columns, Editor's Note, Abstract 등일 경우가 있습니다.]
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
Novel Zn(II) complexes with the general formula: [Zn(furo)2(L)n], n = 1 or 2, (furo = furosemide = (4‐chloro‐2‐(furan‐2‐ylmethylamino)‐5‐sulfamoylbenzoic acid) were prepared. The complexes [Zn(furo)2(MeOH)2] (1; MeOH = methanol),...
Novel Zn(II) complexes with the general formula: [Zn(furo)2(L)n], n = 1 or 2, (furo = furosemide = (4‐chloro‐2‐(furan‐2‐ylmethylamino)‐5‐sulfamoylbenzoic acid) were prepared. The complexes [Zn(furo)2(MeOH)2] (1; MeOH = methanol), [Zn(furo)2(2‐ampy)2] (2; 2‐ampy = 2‐aminopyridine), [Zn(furo)2(2‐ammepy)2] (3; 2‐ammepy = 2‐aminomethylpyridine), [Zn(furo)2(H2O)(2,2‐bipy)] (4; 2,2′‐bipy = 2,2′‐bipyridine), [Zn(furo)2(H2O)(4,4′‐bipy)] (5; 4,4′‐bipy = 4,4′‐bipyridine), [Zn(furo)2(1,10‐phen)] (6; 1,10‐phen = 1,10‐phenanthroline), [Zn(furo)2(2,9‐dmp)] (7; 2,9‐dmp = 2,9‐dimethyl‐1,10‐phenanthroline), and [Zn (furo)2(quin)2] (8; quin = quinoline) were synthesized and characterized using different techniques such as IR, UV–Vis, 1H NMR, 13C NMR, LC/MS and others. The crystal structure of complex (4) was determined using single‐crystal X‐ray diffraction.
The anti‐bacterial activity of complexes (1–8) was tested using agar diffusion method against three gram‐positive (Staphylococcus aureus, Bacillus subtilis and Staphylococcus epidermidis) and three gram‐negative bacteria (Escherichia coli, Proteus mirabilis, Pseudomonas aeruginosa). The obtained results showed different Inhibition Zone Diameters (IZD) with various anti‐bacterial activities against the selected gram‐positive and gram‐negative bacteria.
In addition, the rate of bis‐(4‐nitrophenyl) phosphate hydrolysis was measured at different temperatures, different pH values and different concentrations. The rates for the eight complexes were in the following order: complex 4 > 2 > 5 > 8 > 7 > 6 > 3 > 1.
Zinc furosemide was reacted with different molar ratios of nitrogen based ligands to form zinc furosemide complexes. The rate of BNPP hydrolysis was tested in order to determine the effect of zinc complexes on the phosphates hydrolysis. The crystal structure of complex 4 was determined.