In this study, we investigated the antioxidant activity of hesperidin and hesperetin, which are the active compounds from Citrus junos, in the cellular system. Under cellular model of oxidative damage using LLC-PK<SUB>1</SUB> renal epithel...
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https://www.riss.kr/link?id=A109159849
2011
Korean
Hesperidin ; Hesperetin ; Oxidative stress ; LLC-PK< ; SUB> ; 1< ; /SUB> ; renal epithelial cell
520
KCI등재
학술저널
717-722(6쪽)
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
In this study, we investigated the antioxidant activity of hesperidin and hesperetin, which are the active compounds from Citrus junos, in the cellular system. Under cellular model of oxidative damage using LLC-PK<SUB>1</SUB> renal epithel...
In this study, we investigated the antioxidant activity of hesperidin and hesperetin, which are the active compounds from Citrus junos, in the cellular system. Under cellular model of oxidative damage using LLC-PK<SUB>1</SUB> renal epithelial cell, the oxidative damage induced by 2,2-azobis (2-amidinopropane) dihydrochloride (AAPH) led to the loss of cell viability, while treatment of hesperidin and hesperetin increased significantly the cell viability as dose-dependent manner. In addition, NO-induced cellular oxidative damage by sodium nitroprusside were significantly recovered by the treatment of hesperidin and hesperetin, showing the increase of cell viability. But hesperidin and hesperetin showed no significant protective effect on O<SUB>2</SUB><SUP>-</SUP>-induced cellular oxidative damage. The present study indicates that hesperidin and hesperetin protect against free radical, especially AAPH-induced peroxyl radical. In particular, hesperetin has stronger protective effect against oxidative stress than hesperidin.
목차 (Table of Contents)
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