임산부 및 신생아에서 B형간염 표식자의 발현양상에 관한 연구 = Study on the Hepatitis B Markers Expressed in Term Pregnant Women and Their Babies

국문 초록 (Abstract)

1991년 7월부터 1992년 12월까지 이화대학교병원 산부인과에 분만을 위해 내원한 임산부중 HBsAg 선별검사에서 HBsAg양성인 임산부 88례를 대상으로 방사면역측정법을 사용하여 Anti-HBs, HBeAg, Anti-HBe, Anti-HBc를 검사하였고, 신생아의 HBsAg, HBeAg를 검사하여 임산부와 신생아간에 B형간임 표식자의 관계를 분석한 결과 다음과 같은 결론을 얻었다.
1. 임산부 B형 간염의 감염빈도는 2.68%였다.
2. HBsAg이 처음 검출된 시기는 산전진료중이나 분만시에 HBsAg양성을 알게 된 경우가 69.3%였고, 경과된 기간은 1년미만(48.9%)에서 5년이상 (14.8%)경과된 예도 있었다.
3. HBsAg양성인 임산부에서 출생한 신생아의 HBsAg양성율은 7.9%였다.
4. HBsAg양성인 임산부 중 HBeAg양성인 임산부는 51.1%, Anti-HBe양성인 임산부는 44.3%였다.
5. 신생아의 HBsAg양성율은 HBeAg양성인 임산부에서 HBeAg음성인 임산부에 비해 유의하게 높았다. 또한 신생아의 HBeAg양성율 역시 HBeAg 양성인 임산부에서 HBeAg 음성인 임산부에 비해 유의하게 높았다.
6. 신생아의 HBsAg 양성율은 임산부의 Anti-HBc양성 및 음성에 따라 유의한 차이가 없었다.
7. 임산부의 HBeAg 양성율은 임산부의 Anti-HBc양성 및 음성에 따라 유의한 차이가 없었고, 신생아의 HBeAg양성율도 임산부의 Anti-HBc양성 및 음성에 따라 유의한 차이가 없었다. 결론적으로 산전진료시 상례적인 임산부의 HBsAg선별검사는 매우 의의가 있으며, 이에 따른 신생아의 확실한 예방법으로 감염을 차단하여야 할 것이다.

다국어 초록 (Multilingual Abstract)

This study was tried to evaluate the relation between the hepatitis B markers of pregnant women and their babies in hepatitis B surface antigen (HBsAg) positive mothers. Hepatitis B markers were checked by radioimmunoassay for 88 HBsAg positive mothers who delivered at the Department of Obstetrics and Gynecology in Ewha Womans University Hospital and their babies and analyzed the relation between the pregnant mothers and their babies.
The results were as follows:
1. The incidence of positive HBsAg in term pregnant mothers was 2.68%.
2. HBsAg was detected initially in 69.3% of HBsAg positive pregnant mothers during the prenatal care and delivery and duration from the initial detection of HBsAg in pregnant mothers was variable from less than one year (48.9%) to five or more years(14.8%).
3. Of HBsAg positive mothers, HBsAg was positive in 7.9% of their babies.
4. HBeAg was positive in 51.1% and Anti-HBe was positive in 44.3% of HBsAg positive mothers.
5. Positive rate of HBsAg and HBeAg in the babies were significantly higher in HBeAg positive mothers than in HBeAg negative mothers.
6. HBsAg positive rate of the babies was not significantly different between Anti-HBc positive and negative mothers.
7. HBeAg positive rate of the mothers was not significantly different between Anti-HBc positive and negative mothers and HBeAg positive rate of the babies was not significantly different between Anti-HBc positive and negative mothers.
In conclusion, routine prenatal screening for hepatitis B virus in pregnant women is essential for the protection against B virus hepatitis with immunoprophylaxis in their babies.