HIV 감염 환자에 대한 약물 치료기법 설계 = 외란관측기 기반 제어기 기법

다국어 초록 (Multilingual Abstract)

In this paper, we propose a drug treatment protocol for the three state HIV infection model that explicitly includes the concentration of healthy T cells, infected T cells, and HIV. While most of the previous methods are not able to achieve the treatment goal in the presence of modelling errors, the proposed method is designed so as to compensate for the model uncertainties. Based on the Jacobain linearization of nonlinear HIV infection model, disturbance observer(DOB) based control is employed to design the drug treatment for the HIV patients. Computer simulation is carried out for nonlinear model in order to compare the performance of the proposed method with that of the conventional technique. The simulation results show that, in the presence of parameter uncertainties, the substantial improvement in the performance can be achieved by the proposed DOB controller.

목차 (Table of Contents)

• Abstract
• 1. 서론
• 2. HIV 감염 모형
• 3. 외란 관측기
• 4. 모의실험
• 5. 결론
• References

참고문헌 (Reference)

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4 C. A. Janeway, "Immunobiology: The immune system in health and disease, 6th Ed." Garland Pub 2004

5 Dr Pedram Sendi, "Highly active antiretroviral therapy" 19 (19): 709-713, 2001

6 S.K. Stanley, "Guidelines for the use of antiretroviral agents in HIV-infected adults and adolescents" 47 (47): 39-41, 1998

7 I. Craig, "Can HIV/AIDS be controlled ?" 25 : 80-83, 2005

8 H. Shim, "An almost necessary and sufficient conditions for robust stability of closed-loop systems with disturbance observer" 45 (45): 296-299, 2009

9 R. Zurakowski, "A model predictive control based scheduling method for hiv therapy" 238 (238): 368-382, 2006