Background The purposes of this study were to evaluate the effect of hormon replacement therapy & vitamin-D on the bone mineral density and bone metabolism in the postmenopausal women, and to compare the effect of vitamin D alone with those of premari...
Background The purposes of this study were to evaluate the effect of hormon replacement therapy & vitamin-D on the bone mineral density and bone metabolism in the postmenopausal women, and to compare the effect of vitamin D alone with those of premarine or premarin plus vitamin D. Method 150 postmenopausal women were randomly submitted to the 3 groups of treatment with 0.5㎍ of vitamin D daily by oral administration (Group I), 0.625mg of premarine once a day (Group II), and 0.625mg of premarine once a day plus 0.5㎍ of vitamin D daily by oral administration (Group III). In all subjects, bone mineral density (BMD) of lumbar spine and femur neck, urinary calcium/creatinine ratio, and serum osteocalcin were measured before treatment and after 6 and 12 months of treatment. Results BMD of femur neck in Group I, Group II and Group III increased but not significantly compared to basal level at 6 months and/or 12 months of treatment. As for BMD of lumbar spine, it increased significantly during the treatment in Group II and Group III, but not in Group I. Serum osteocalcin in Group II and Group III decreased significanly at 12 months of treatment compared with Group I. Urinary calcium/creatinine ratio & urine deoxypiridinoline in Group II, Group III, decreased significantly at 12 months of treatment compared with Group I. Conclusion From the above results, it might be suggested that combined therapy is more effective in post menopausal women with the protection on decreasing bone mineral density.