Angiotensin Converting Enzyme Inhibitor에 의해 유발된 약제 유발 루푸스 1예 = A Case of Angiotensin Converting Enzyme Inhibitor-Induced Systemic Lupus Erythematosus

국문 초록 (Abstract)

약제 유발 루푸스에 대한 여러 증례들이 보고되어 왔으나 ACE inhibitor에 의한 약제 유발 루푸스에 대한 증례는 없었다. ACE inhibitor에 의한 루푸스의 정확한 병리 기전은 밝혀지지 않았으나 고혈압과 심장질환의 다양한 환자에서 쓰이고 있는바 임상증상 추이를 관찰하면서 발생에 대해 염두 해둘 필요가 있다. 저자들은 불안정성 협심증환자에서 ACE inhibitor 사용 도중 발생한 약제 유발 루푸스 1예를 경험하였기에 이를 보고하는 바이다.

다국어 초록 (Multilingual Abstract)

Drug-induced lupus erythematosus is defined as a lupus-like syndrome related to continuous drug exposure which resolves after discontinuation of the offending drug. Here we report a case of a 70-year-old man who developed drug-induced lupus erythematosus after receiving angiotensin converting enzyme inhibitor medication for unstable angina pectoris, for 5 years. He was hospitalized with arthralgia, edema, and newly developed pleural effusion. The serum analysis revealed an elevated level of antinuclear antibody and antihistone antibody. After discontinuation of angiotensin converting enzyme inhibitor and receiving a course of prednisolone treatment, his symptoms and pleural effusion improved. To the best of our knowledge, this is, the first case report of angiotensin converting enzyme inhibitor-induced systemic lupus erythematosus in Korea.

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